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AR420626 (CAS 1798310-55-0) LS-H140

FFAR3 agonist, GPR41 agonist
LS-H140-500 / 500 µg / $185
LS-H140-1000 / 1000 µg / $205
LS-H140-5000 / 5000 µg / $335
LS-H140-10000 / 10000 µg / $405
USA Shipment Only
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Description: Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). It is expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation. AR420626 is a selective agonist of FFAR3 (GPR41; IC50 = 117 nM) that does not activate the related receptor FFAR2 (GPR43) at concentrations up to 100 µM. At 10 µM, it can stimulate a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures. H140_ChemicalStructureImage.png
?N-(2,5-dichlorophenyl)-4-(2-furanyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxamide
 
biochemical, chemical, agonist
LS-H140
1798310-55-0
C21H18Cl2N2O3
≥95%
A crystalline solid
 
ClC1=CC(NC(C2=C(C)NC(CCCC3=O)=C3C2C4=CC=CO4)=O)=C(Cl)C=C1
InChI=1S/C21H18Cl2N2O3/c1-11-18(21(27)25-15-10-12(22)7-8-13(15)23)20(17-6-3-9-28-17)19-14(24-11)4-2-5-16(19)26/h3,6-10,20,24H,2,4-5H2,1H3,(H,25,27)
GGTYQECCGLBHGS-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: FFAR3 / GPR41 related products

Usage Information

AR420626 is supplied as a crystalline solid. A stock solution may be made by dissolving the AR420626 in the solvent of choice. AR420626 is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of AR420626 in these solvents is approximately 5 and 2 mg/ml, respectively. AR420626 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, AR420626 should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. AR420626 has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Inoue, D., Tsujimoto, G., and Kimura, I. Regulation of energy homeostasis by GPR41. Front. Endocrinol. (Lausanne) 5, 1-3 (2014).
  2. Engelstoft, M.S., Park, W., Sakata, I., et al. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol. Metab. 2(4), 376-392 (2013).
  3. Nøhr, M.K., Pedersen, M.H., Gille, A., et al. GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. Endocrinology 154(10), 3552-3564 (2013).

 


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