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6-OAU (CAS 83797-69-7) LS-H145

GPR84 agonist
LS-H145-1 / 1 mg / $205
LS-H145-5 / 5 mg / $365
LS-H145-10 / 10 mg / $515
USA Shipment Only
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Description: GPR84 is a G alpha i protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations. GPR84 is expressed in leukocytes and its expression is further induced by LPS. 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM). It has insignificant actions at a panel of 69 other receptors, channels, or transporters. 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF- alpha production by LPS-treated U937 macrophages. In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated alpha protein) when delivered intravenously. H145_ChemicalStructureImage.png
6-(octylamino)-2,4(1H,3H)-pyrimidinedione
 
biochemical, chemical, agonist
LS-H145
83797-69-7
C12H21N3O2
≥98%
A crystalline solid
 
O=C1NC(NCCCCCCCC)=CC(N1)=O
InChI=1S/C12H21N3O2/c1-2-3-4-5-6-7-8-13-10-9-11(16)15-12(17)14-10/h9H,2-8H2,1H3,(H3,13,14,15,16,17)
PFSWASUQURIOOR-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: GPR84 related products

Usage Information

6-OAU is supplied as a crystalline solid. A stock solution may be made by dissolving the 6-OAU in the solvent of choice. 6-OAU is soluble in organic solvents such DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of 6-OAU in these solvents is approximately 0.25 mg/ml. 6-OAU is sparingly soluble in aqueous solutions. To enhance aqueous solubility, dilute the organic solvent solution into aqueous buffers or isotonic saline. If performing biological experiments, ensure the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Davenport, A.P., Alexander, S.P.H., Sharman, J.L., et al. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: Recommendations for new pairings with cognate ligands. Pharmacol. Rev. 65(3), 967-986 (2013).
  2. Suzuki, M., Takaishi, S., Nagasaki, M., et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J. Biol. Chem. 288(15), 10684-10691 (2013). O N H N H O N H Product Information Cayman Chemical Mailing address 1180 E. Ellsworth Road Ann Arbor, MI 48108 USA Phone (800) 364-9897 (734) 971-3335 Fax (734) 971-3640 E-Mail custserv@caymanchem.com Web www.caymanchem.com

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