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3-methoxy Limaprost (CAS 1224443-96-2) LS-H19

FP receptor antagonist
LS-H19-500 / 500 µg / $195
LS-H19-1000 / 1000 µg / $215
LS-H19-5000 / 5000 µg / $405
LS-H19-10000 / 10000 µg / $635
USA Shipment Only
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Description: Limaprost is an analog of prostaglandin E1 (PGE1) with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an inhibitor of ADP and collagen-induced platelet aggregation and is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. 3-methoxy Limaprost results from the Michael addition of methanol to the limaprost 2,3 double bond. The resulting novel compound is likely to retain FP receptor agonist activity; however there are no published studies of the pharmacological properties of 3-methoxy limaprost. H19_ChemicalStructureImage.png
3-methoxy-11α,15S-dihydroxy-17S,20-dimethyl-9-oxo-prosta-13E-en-1-oic acid
3-methoxy-2,3-dihydro-Limaprost
3-methoxy-17α,20-dimethyl-Δ2-ProstaglandinE1
biochemical, chemical, antagonist
LS-H19
1224443-96-2
C23H40O6
≥98%
A solution in methyl acetate
0
O[C@@H]([C@H](/C=C/[C@@H](O)C[C@@H](C)CCCC)[C@H]1CCCCC(OC)CC(O)=O)CC1=O
InChI=1S/C23H40O6/c1-4-5-8-16(2)13-17(24)11-12-20-19(21(25)15-22(20)26)10-7-6-9-18(29-3)14-23(27)28/h11-12,16-20,22,24,26H,4-10,13-15H2,1-3H3,(H,27,28)/b12-11+/t16-,17+,18?,19+,20+,22+/m0/s1
CQMVTHTYLSWGRI-HMHRGJHKSA-N
Shipped Ambient, store at -20°C, ≥ 1 year shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: FP / PTGFR related products

Usage Information

3-methoxy Limaprost is supplied as a solution in methyl acetate. To change the solvent, simply evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice. Solvents such as ethanol, DMSO, and dimethyl formamide purged with an inert gas can be used. The solubility of 3-methoxy limaprost in these solvents is approximately 30 mg/ml. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. If an organic solvent-free solution of 3-methoxy limaprost is needed, it can be prepared by evaporating the methyl acetate and directly dissolving the neat oil in aqueous buffers. The solubility of 3-methoxy limaprost in PBS, pH 7.2, is approximately 1 mg/ml. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch. Int. Pharmacodyn. 247, 89-102 (1980).

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