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25-hydroxy Vitamin D2 (CAS 21343-40-8) LS-H87

Vitamin D receptor agonist
LS-H87-500 / 500 µg / $235
LS-H87-1000 / 1000 µg / $295
LS-H87-5000 / 5000 µg / $875
USA Shipment Only
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Description: Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. Vitamin D2 is produced in fungi, including yeast, from ergosterol in response to ultraviolet radiation. 25-hydroxy Vitamin D2 is an intermediate produced from vitamin D2 by cytochrome P450 isoforms in vertebrates. It is subsequently metabolized to 1,25-dihydroxy vitamin D2, which is an agonist for the vitamin D receptor. H87_ChemicalStructureImage.png
4-methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexenyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-cyclohexanol
Ercalcidiol
25-Hydroxyergocalciferol
biochemical, chemical, agonist
LS-H87
21343-40-8
C28H44O2
≥98%
A crystalline solid
 
C=C1CC[C@H](O)C/C1=C\C=C2CCC[C@@]3(C)[C@@]\2([H])CC[C@]3([H])[C@H](C)/C=C/[C@H](C)C(C)(O)C
InChI=1S/C28H44O2/c1-19-10-14-24(29)18-23(19)13-12-22-8-7-17-28(6)25(15-16-26(22)28)20(2)9-11-21(3)27(4,5)30/h9,11-13,20-21,24-26,29-30H,1,7-8,10,14-18H2,2-6H3/b11-9+,22-12-,23-13+/t20-,21+,24+,25-,26+,28-/m1/s1
KJKIIUAXZGLUND-UURWAHJLSA-N
Shipped at 4°C, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: Vitamin D Receptor / VDR related products

Usage Information

25-hydroxy Vitamin D2 is supplied as a crystalline solid. A stock solution may be made by dissolving the 25-hydroxy vitamin D2 in the solvent of choice. 25-hydroxy Vitamin D2 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of 25-hydroxy vitamin D2 in these solvents is approximately 20 mg/ml. 25-hydroxy vitamin D2 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, 25-hydroxy vitamin D2 should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. 25-hydroxy Vitamin D2 has a solubility of approximately 0.3 mg/ml in a 1:2 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Holick, M.F. Vitamin D deficiency. N. Engl. J. Med. 357(3), 266-281 (2007).
  2. Peterlik, M., Boonen, S., Cross, H.S., et al. Vitamin D and calcium insufficiency-related chronic diseases: An emerging world-wide public health problem. Int. J. Environ. Res. Public Health 6, 2585-607 (2009).
  3. Gravellone, L., Rizzo, M.A., Martina, V., et al. Vitamin D receptor activators and clinical outcomes in chronic kidney disease. Int. J. Nephrol. 2011, (2011).

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