LSBio
Products
  • Antibodies
  • All Antibodies
  • Primary Antibodies
  • Secondary Antibodies
  • IHC-plus Antibodies
  • Isotype Control Antibodies
  • ELISA and Assay Kits
  • All Kits
  • Assay Kits
  • Traditional ELISA Kits
  • Cell-Based ELISA Kits
  • DNA-Binding ELISA Kits
  • Phospho-Specific ELISA Kits
  • ELISA Development Kits
  • Chemiluminescent CLIA Kits
  • Proteins
  • All Proteins
  • Recombinant Proteins
  • Native Proteins
  • Over-expression Lysates
  • Cell and Tissue Lysates
  • Bio-active Proteins
  • Animal-free Proteins
  • Synthetic Peptides
  • Biochemicals
  • All Biochemicals

  • Immunohistochemistry
  • Comprehensive IHC Reports
  • Custom IHC Services
  • TCR Screening Services
  • IHC-plus Antibodies
Services
  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Have a question? CustomerSupport@LSBio.com
Resources
  • Purchasing
  • Product Ordering Terms and Conditions
  • Holiday Schedule
  • About the LSBio Guarantee
  • About Our Rewards Program
  • Reference Material
  • About LSBio (LifeSpan BioSciences Inc.)
  • About Our 2-million Specimen Tissue Bank
  • About Our IHC Validation Process
  • About Our IHC-plus™ Immunohistochemistry Protocol
  • Protocols
  • Secure Logins
  • Login to Our Secure ShareFile Site
  • Login to Our IHC Database
Distributors
Contact Us

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)
How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login ▾
Wish List
View Cart

2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine (CAS 133240-06-9) LS-H144

Angiotensin II receptor antagonist
LS-H144-100 / 100 mg / $205
LS-H144-250 / 250 mg / $265
LS-H144-500 / 500 mg / $335
USA Shipment Only
Order Button
100% Guaranteed 100% Guaranteed

Description: 2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is a nonpeptidic angiotensin II receptor antagonist whose imidazo[4,5-b]pyridine scaffold has been used to examine a variety of positional substitutions in the development of orally active, long duration antihypertensive agents. H144_ChemicalStructureImage.png
2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
 
biochemical, chemical, antagonist
LS-H144
133240-06-9
C10H13N3
≥98%
A crystalline solid
 
CC1=CC(C)=C2C(N1)=NC(CC)=N2
InChI=1S/C10H13N3/c1-4-8-12-9-6(2)5-7(3)11-10(9)13-8/h5H,4H2,1-3H3,(H,11,12,13)
XWWJWZJOSWSJQV-UHFFFAOYSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: AGTR2 / AT2 Receptor related products

Usage Information

2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is supplied as a crystalline solid. A stock solution may be made by dissolving the 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine in the solvent of choice. 2-Ethyl-5,7-dimethyl-3Himidazo[4,5-b]pyridine is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine in these solvents is approximately 10, 20, and 30 mg/ml, respectively. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. 2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is sparingly soluble in aqueous buffers. The solubility of 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine in PBS, pH 7.2, is approximately 0.25 mg/ml. For maximum solubility in aqueous buffers, 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine should first be dissolved in DMF and then diluted with the aqueous buffer of choice. 2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Mantlo, N.B., Chakravarty, P.K., Ondeyka, D.L. , et al. Potent, orally active Imadazo[4,5-b]pyridine-based angiotensin II receptor antagonists. J. Med. Chem. 34(9), 2919-2922 (1991).

Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2017 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy
Catalog Number