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16(R)-AFP 07 (free acid) (CAS 773825-80-2) LS-H73

IP receptor agonist
LS-H73-500 / 500 µg / $315
LS-H73-1000 / 1000 µg / $465
LS-H73-5000 / 5000 µg / $1890
USA Shipment Only
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Description: Prostaglandin I2 is an unstable prostanoid which, through the 'prostanoid' (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM). AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4. 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated. H73_ChemicalStructureImage.png
5Z-[3aR,3-difluorohexahydro-5R-hydroxy-4R-[3R-hydroxy-4S-methyl-1E-nonen-6aS-ynyl]-2Hcyclopenta[b]furan-2-ylidene]-pentanoic acid
biochemical, chemical, agonist
A solution in methyl acetate
Shipped at 4°C, store at -20°C, ≥ 1 year shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: PTGIR / IP Receptor related products

Usage Information

16(R)-AFP 07 (free acid) is supplied as a solution in methyl acetate. To change the solvent, simply evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice. Solvents such as ethanol, DMSO, and dimethyl formamide purged with an inert gas can be used. The solubility of 16(R)-AFP 07 (free acid) in these solvents is approximately 25 mg/ml. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. If an organic solvent-free solution of 16(R)-AFP 07 (free acid) is needed, it can be prepared by evaporating the methyl acetate and directly dissolving the neat oil in aqueous buffers. The solubility of 16(R)-AFP 07 (free acid) in PBS, pH 7.2, is approximately 1 mg/ml. We do not recommend storing the aqueous solution for more than one day.

  1. Chang, C., Negishi, M., Nakano, T., et al. 7,7-Difluoroprostacyclin derivative, AFP-07, a highly selective and potent agonist for the prostacyclin receptor. Prostaglandins 53, 83-90 (1997).
  2. Jones, R.L. and Chan, K. Distinction between relaxations induced via prostanoid EP4 and IP1 receptors in pig and rabbit blood vessels. Br. J. Pharmacol. 134, 313-324 (2001).


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