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1-hydroxy Vitamin D2 (CAS 54573-75-0) LS-H86

Vitamin D receptor agonist
LS-H86-1 / 1 mg / $185
LS-H86-5 / 5 mg / $245
LS-H86-10 / 10 mg / $295
USA Shipment Only
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Description: Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. 1-hydroxy Vitamin D2 is a synthetic prodrug of the active 1,25-dihydroxy vitamin D2, as well as of other active metabolites. It is used to suppress the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism, an action which requires vitamin D receptor. 1-hydroxy Vitamin D2 is effective in stimulating bone growth and, in combination therapy with angiotensin receptor blockers, ameliorates albuminuria and glomerulosclerosis associated with diabetic nephropathy. It also inhibits the growth of certain blastomas and prostate cancer cells. H86_ChemicalStructureImage.png
4-methylene-5Z-[2E-[(1R,3aS)-octahydro-7aR-methyl-1R-[1R,4,5-trimethyl-2E-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3S-cyclohexanediol
Doxercalciferol
Hectorol
1-Hydroxyergocalciferol
TSA840
biochemical, chemical, agonist
LS-H86
54573-75-0
C28H44O2
≥98%
A crystalline solid
 
C[C@@]12[C@](CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(C)C)([H])/C(CCC1)=C/C=C3C[C@@H](O)C[C@H](O)C/3=C
InChI=1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11-,23-12+/t19-,20+,24+,25+,26-,27-,28+/m0/s1
HKXBNHCUPKIYDM-VHKYCACESA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: Vitamin D Receptor / VDR related products

Usage Information

1-hydroxy Vitamin D2 is supplied as a crystalline solid. A stock solution may be made by dissolving the 1-hydroxy vitamin D2 in the solvent of choice. 1-hydroxy Vitamin D2 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of 1-hydroxy vitamin D2 in these solvents is approximately 20 mg/ml. 1-hydroxy Vitamin D2 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, 1-hydroxy vitamin D2 should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. 1-hydroxy Vitamin D2 has a solubility of approximately 0.3 mg/ml in a 1:2 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Holick, M.F. N. Engl. J. Med. 357(3), 266-281 (2007).
  2. Peterlik, M., Boonen, S., Cross, H.S., et al. Int. J. Environ. Res. Public Health 6, 2585-607 (2009).
  3. Upton, R.A., Knutson, J.C., Bishop, C.W., et al. Nephrol. Dial. Transplant. 18, 750-758 (2003).
  4. Frazao, J.M., Chesney, R.W., Coburn, J.W., et al. Nephrol. Dial. Transplant. 13, 68-72 (1998).
  5. Brown, A.J., Dusso, A.S., and Slatopolsky, E. Nephrol. Dial. Transplant. 17, 10-19 (2002).
  6. Nguyen-Yamamoto, L., Bolivar, I., Strugnell, S.A., et al. J. Am. Soc. Nephrol. 21, 1713-1723 (2010).
  7. Zhang, Y., Deb, D.K., Kong, J., et al. Am. J. Physiol. Renal Physiol. 297, F791-F801 (2009).
  8. van Ginkel, P.R., Yang, W., Marcet, M.M., et al. J. Neurooncol. 85, 255-262 (2007).
  9. Attia, S., Eickhoff, J., Wilding, G., et al. Clin. Cancer Res. 14(8), 2437-2443 (2008).

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