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1,25-dihydroxy Vitamin D2 (CAS 60133-18-8) LS-H76

Vitamin D receptor agonist
LS-H76-500 / 500 µg / $205
LS-H76-1000 / 1000 µg / $245
LS-H76-5000 / 5000 µg / $515
USA Shipment Only
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Description: 1,25-dihydroxy Vitamin D2 is the active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney. By binding to the vitamin D receptor (VDR), 1,25-dihydroxy Vitamin D2 activates VDR to interact with the retinoid X receptor (RXR), forming the VDR/RXR/cofactor complex, which regulates gene transcription. Because 1,25-dihydroxy Vitamin D2 circulates at picomolar concentrations and is highly lipophilic, it is difficult to quantify. H76_ChemicalStructureImage.png
(1R,3S,5Z)-4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
Ercalcitriol
Ro17-6218
biochemical, chemical, agonist
LS-H76
60133-18-8
C28H44O3
≥98%
A crystalline solid
 
O[C@H]1C[C@H](O)C(/C(C1)=C\C=C2CCC[C@@]3(C)[C@@]/2([H])CC[C@]3([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C)=C
InChI=1S/C28H44O3/c1-18(9-10-19(2)27(4,5)31)24-13-14-25-21(8-7-15-28(24,25)6)11-12-22-16-23(29)17-26(30)20(22)3/h9-12,18-19,23-26,29-31H,3,7-8,13-17H2,1-2,4-6H3/b10-9+,21-11+,22-12-/t18-,19+,23-,24-,25+,26+,28-/m1/s1
ZGLHBRQAEXKACO-XJRQOBMKSA-N
Shipped at 4°C, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: Vitamin D Receptor / VDR related products

Usage Information

Ercalcitriol is supplied as a crystalline solid. A stock solution may be made by dissolving the ercalcitriol in the solvent of choice. Ercalcitriol is soluble in ethanol, which should be purged with an inert gas. The solubility of ercalcitriol in ethanol is approximately 1 mg/ml. Ercalcitriol is sparingly soluble in aqueous solutions. To enhance aqueous solubility, dilute the organic solvent solution into aqueous buffers or isotonic saline. If performing biological experiments, ensure the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Sudsakorn, S., Phatarphekar, A., O’Shea, T., et al. Determination of 1,25-dihydroxyvitamin D2 in rat serum using liquid chromatography with tandem mass spectrometry. J. Chromatogr. B 879, 139-145 (2011).
  2. Kato, S., Kim, M.-S., Yamaoka, K., et al. Mechanisms of transcriptional repression by 1,25(OH)2 vitamin D. Curr. Opin. Nephrol. Hypertens. 16, 297-304 (2007).

 


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