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1,24-dihydroxy Vitamin D3 (CAS 57333-96-7) LS-H88

Vitamin D receptor agonist
LS-H88-500 / 500 µg / $225
LS-H88-1000 / 1000 µg / $275
LS-H88-5000 / 5000 µg / $740
USA Shipment Only
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Description: Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. In addition, the active form of vitamin D, 1,25-dihydroxy vitamin D3, decreases the proliferation and increases differentiation of keratinocytes. 1,24-dihydroxy Vitamin D3 is an analog of 1,25-dihydroxy vitamin D3 which, when used in a 4 µg/g ointment, safely and effectively suppresses psoriasis. It also is effective at increasing the time interval between phototherapy cycles when ultraviolet light is used for psoriasis. 1,24-dihydroxy Vitamin D3 inhibits the growth of both normal and psoriatic human keratinocytes (IC50 ~ 10 nM) via the vitamin D receptor. It also suppresses the production of RANTES and IL-8 by human dermal fibroblasts and reduces cutaneous lymphocyte-associated antigen on CD4+ T cells, impairing migration and skin infiltration.<sup class="reference H88_ChemicalStructureImage.png
4-methylene-5Z-[2E-[(3aS)-octahydro-1R-[4R-hydroxy-1R,5-dimethylhexyl]-7aR-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol
Bonalfa
Curatoderm
1α,24(R)-Dihydroxycholecalciferol
PRI2191
Tacalcitol
TV02
biochemical, chemical, agonist
LS-H88
57333-96-7
C27H44O3
≥98%
A crystalline solid
 
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](O)C(C)C)([H])/C(CCC1)=C/C=C3C[C@@H](O)C[C@H](O)C/3=C
InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1
BJYLYJCXYAMOFT-RSFVBTMBSA-N
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: Vitamin D Receptor / VDR related products

Usage Information

1,24-dihydroxy Vitamin D3 is supplied as a crystalline solid. A stock solution may be made by dissolving the 1,24-dihydroxy vitamin D3 in the solvent of choice. 1,24-dihydroxy Vitamin D3 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of 1,24-dihydroxy vitamin D3 in these solvents is approximately 20 mg/ml. 1,24-dihydroxy Vitamin D3 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, 1,24-dihydroxy vitamin D3 should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. 1,24-dihydroxy Vitamin D3 has a solubility of approximately 0.3 mg/ml in a 1:3 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Holick, M.F. N. Engl. J. Med. 357(3), 266-281 (2007).
  2. Peterlik, M., Boonen, S., Cross, H.S., et al. Int. J. Environ. Res. Public Health 6, 2585-607 (2009).
  3. Bikle, D.D. J. Nutr. 125, 1709S-1714S (1995).
  4. Leone, G. and Pacifico, A. Acta. Biomed. 76, 13-19 (2005).
  5. Prignano, F., Buggiani, G., and Lotti, T. Acta. Biomed. 80, 51-56 (2009).
  6. Fukuoka, M., Ogino, Y., Sato, H., et al. Br. J. Pharmacol. 124(7), 1433-1438 (1998).
  7. Yamanaka, K.-I., Kakeda, M., Kitagawa, H., et al. Br. J. Dermatol. 162(6), 1206-1215 (2010).

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