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(S)-(-)-Propranolol (hydrochloride) (CAS 839971) LS-H134

Beta-adrenergic receptor antagonist
LS-H134-50 / 50 mg / $175
LS-H134-100 / 100 mg / $195
LS-H134-250 / 250 mg / $235
LS-H134-500 / 500 mg / $305
USA Shipment Only
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Description: (S)-(-)-Propranolol is the active enantiomer of propranolol, a beta -adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for beta 1, beta 2, and beta 3, respectively. It is also a non-specific serotonin receptor antagonist. Propanolol was one of the first beta -adrenergic receptor blockers to be widely used in clinical practice for the treatment of hypertension, angina pectoris, and cardiac ischemia. H134_ChemicalStructureImage.png
1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2S-propanol, monohydrochloride
 
biochemical, chemical, antagonist
LS-H134
839971
C16H21NO2 • HCl
≥98%
A crystalline solid
 
CC(C)NC[C@H](O)COC1=C2C(C=CC=C2)=CC=C1.Cl
InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m0./s1
ZMRUPTIKESYGQW-UQKRIMTDSA-N
Shipped at 4°C, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: ADRB1 related products

Usage Information

(S)-(-)-Propranolol (hydrochloride) is supplied as a crystalline solid. A stock solution may be made by dissolving the (S)-(-)-propranolol (hydrochloride) in the solvent of choice. (S)-(-)-Propranolol (hydrochloride) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of (S)-(-)-propranolol (hydrochloride) in these solvents is approximately 11, 16, and 14 mg/ml, respectively. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of (S)-(-)-propranolol (hydrochloride) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of (S)-(-)-propranolol (hydrochloride) in PBS, pH 7.2, is approximately 5 mg/ml. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005).
  2. Mehvar, R. and Brocks, D.R. Stereospecific pharmacokinetics and pharmacodynamics of β-adrenergic blockers in humans. J. Pharm. Pharm. Sci. 4(2), 185-200 (2001).
  3. Costain, D.W. and Green, A.R. β-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine. Br. J. Pharmacol. 64(2), 193-200 (1978).
  4. Gerber, J.G., Freed, C.R., and Nies, A.S. Antihypertensive pharmacology. West. J. Med. 132(5), 430-439 (1980).

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