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(R,S)-Atenolol (CAS 29122-68-7) LS-H133

Beta 1-adrenergic receptor antagonist
LS-H133-1 / 1 g / $175
LS-H133-5 / 5 g / $215
LS-H133-10 / 10 g / $235
LS-H133-25 / 25 g / $335
USA Shipment Only
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Description: (R,S)-Atenolol is a beta 1-adrenergic receptor antagonist with Ki values of 1.14 and 48.7 µM for beta 1 and beta 2, respectively. It has been reported that only the (S) enantiomer contributes to the beta-blocking effects of racemic atenolol. Beta-blockers, including atenolol, have diverse applications in cardiology and vascular disease. H133_ChemicalStructureImage.png
biochemical, chemical, antagonist
A crystalline solid
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: ADRB1 related products

Usage Information

(R,S)-Atenolol is supplied as a crystalline solid. A stock solution may be made by dissolving the (R,S)-atenolol in the solvent of choice. (R,S)-Atenolol is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of (R,S)-atenolol in these solvents is approximately 5, 15, and 20 mg/ml, respectively. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of (R,S)-atenolol can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of (R,S)-atenolol in PBS, pH 7.2, is approximately 1 mg/ml. We do not recommend storing the aqueous solution for more than one day.

  1. Golf, S., Bjurnerheim, R., Erichsen, A., et al. Relative selectivity of different β-adrenoceptor antagonists for human heart β1- and β2-receptor subtypes assayed by a radioligand binding technique. Scand. J. Clin. Lab. Invest. 47(7), 719-723 (1987).
  2. Stoschitzky, K., Egginger, G., Zernig, G., et al. Stereoselective features of (R)- and (S)-atenolol: Clinical pharmacological, pharmacokinetic, and radioligand binding studies. Chirality 5(1), 15-9 (1993).
  3. Mehvar, R. and Brocks, D.R. Stereospecific pharmacokinetics and pharmacodynamics of beta-adrenergic blockers in humans. J. Pharm. Pharm. Sci. 4(2), 185-200 (2001).
  4. Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005).


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