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(S)-H-1152 (hydrochloride) (CAS 451462-58-1) LS-H14

ROCK inhibitor
LS-H14-500 / 500 µg / $185
LS-H14-1000 / 1000 µg / $195
LS-H14-5000 / 5000 µg / $315
LS-H14-10000 / 10000 µg / $435
USA Shipment Only
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Description: Rho-associated kinase (ROCK), activated by GTP-linked Rho, phosphorylates targets that are involved in cytoskeletal remodeling, smooth muscle contraction, and neuronal development. H-1152 is a potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM). It is a more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM). H-1152 poorly inhibits PKA, PKC, and myosin light chain kinase (Ki = 0.63, 9.27, and 10.1 µM, respectively). It has been used to examine the role of ROCK in such diverse processes as stress fiber assembly, vasoconstriction, as well as spontaneously tonic smooth muscle and neurite extension. H14_ChemicalStructureImage.png
5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methyl-isoquinoline, dihydrochloride
biochemical, chemical, inhibitor
C16H21N3O2S • 2HCl
A crystalline solid
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: Rho Kinase / ROCK1 related products

Usage Information

(S)-H-1152 (hydrochloride) is supplied as a crystalline solid. To change the solvent, simply evaporate the (S)-H-1152 (hydrochloride) under a gentle stream of nitrogen and immediately add the solvent of choice. Solvents such as ethanol, DMSO, and dimethyl formamide purged with an inert gas can be used. The solubility of (S)-H-1152 (hydrochloride) in these solvents is approximately 20, 12.5, and 15 mg/ml, respectively. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of (S)-H-1152 (hydrochloride) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of (S)-H-1152 (hydrochloride) in PBS, pH 7.2, is approximately 10 mg/ml. We do not recommend storing the aqueous solution for more than one day.

  1. Sasaki, Y., Suzuki, M., and Hidaka, H. Pharmacology & Therapeutics 93, 225-232 (2002).
  2. Ikenoya, M., Hidaka, H., Hosoya, T., et al. J. Neurochem. 81, 9-16 (2002).
  3. Davies, S.L., Gibbons, C.E., Vizard, T., et al. Am J Physiol Cell Physiol 290, C1543-C1551 (2006).
  4. Johnson, R.P., El-Yazbi, A.F., Takeya, K., et al. J Physiol 587(11), 2537-2553 (2009).
  5. Rattan, S. and Patel, C.A. Am J Physiol Gastrointest Liver Physiol 294(3), G687-G693 (2008).

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