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(±)-SLV 319 (CAS 362519-49-1) LS-H29

CB1 receptor antagonist
LS-H29-1 / 1 mg / $175
LS-H29-5 / 5 mg / $225
LS-H29-10 / 10 mg / $285
LS-H29-50 / 50 mg / $725
USA Shipment Only
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Description: Central cannabinoid (CB1) receptor antagonists may have potential in the treatment of a number of diseases such as neuroinflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction, and gastrointestinal disorders. (±)-SLV 319 is the mixture of the CB1 receptor antagonist SLV 319 and its distomer, SLV 319 (+)-enantiomer. SLV 319 is a potent and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and peripheral cannabinoid (CB2), respectively. SLV 319 is less lipophilic (log P = 5.1) and therefore more water soluble than other known CB1 receptor ligands. H29_ChemicalStructureImage.png
biochemical, chemical, antagonist
A crystalline solid
Shipped Ambient, store at -20°C, ≥ 2 years shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: CNR1 / CB1 related products

Usage Information

(±)-SLV 319 is supplied as a crystalline solid. A stock solution may be made by dissolving the (±)-SLV 319 in an organic solvent purged with an inert gas. (±)-SLV 319 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of (±)-SLV 319 in these solvents is approximately 30 mg/ml. (±)-SLV 319 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, (±)-SLV 319 should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. (±)-SLV 319 has a solubility of approximately 0.25 mg/ml in a 1:2 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

  1. Lange, J.H.M., Coolen, H.K.A.C., van Stuivenberg, H.H., et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB1 cannabinoid receptor antagonists. J. Med. Chem. 47(3), 627-643 (2004).
  2. Lange, J.H.M., van Stuivenberg, H.H., Veerman, W., et al. Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. Biooganic & Medicinal Chemistry Letters 15, 4794-4798 (2005).


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