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γ-Linolenic Acid (CAS 506-26-3) LS-H165

LTB4 receptor antagonist
LS-H165-50 / 50 mg / $175
LS-H165-100 / 100 mg / $185
LS-H165-250 / 250 mg / $205
USA Shipment Only
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Description: gamma -Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction. H165_ChemicalStructureImage.png
6Z,9Z,12Z-octadecatrienoic acid
GLA
biochemical, chemical, antagonist
LS-H165
506-26-3
C18H30O2
≥98%
A solution in ethanol
0
CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O
InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/b7-6-,10-9-,13-12-
VZCCETWTMQHEPK-QNEBEIHSSA-N
Shipped Ambient, store at -20°C, ≥ 1 year shelf life.
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Data Sheet DataSheet    SDS SDS
Related Products: Leukotriene B4 Receptor / BLT1 related products

Usage Information

GLA is supplied as a solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. Solvents such as DMSO or dimethyl formamide purged with an inert gas can be used. The solubility of GLA in these solvents is approximately 100 mg/ml. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. If an organic solvent-free solution of GLA is needed, it can be prepared by evaporating the ethanol and directly dissolving the neat oil in aqueous buffers. The solubility of GLA in 0.15 M Tris-HCl (pH 8.5) is approximately 1 mg/ml. We do not recommend storing the aqueous solution for more than one day.

References:
  1. Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot. Essent. Fatty Acids 52, 293-297 (1995).

 


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