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Catalog Number Size Price
LS-K323-100 100 Tests $480 
Acetylcholinesterase Assay Kit

Acetylcholinesterase (AChE) Inhibitor Screening Kit (Color) - LS-K323

Acetylcholinesterase (AChE) Inhibitor Screening Kit (Color) - LS-K323

Available for shipment within the USA only
Description:
ACETYLCHOLINESTERASE (EC 3.1.1.7, AChE), also known as RBC cholinesterase, is found primarily in the blood and neural synapses. AChE catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. Inhibition of the enzyme leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. AChE inhibition is an important target for the management of Alzheimer's disease and AChE inhibitors are the most common drugs used for its management. In addition to Alzheimer's disease, AChE inhibitors have been useful in the diagnosis or treatment of diseases such as glaucoma, myasthenia gravis, bladder distention, and more. BioAssay Systems' QuantiChromTM Acetylcholinesterase Inhibitor Screening kit is based on an improved Ellman method, in which thiocholine produced by the action of acetylcholinesterase forms a yellow color with 5,5'-dithiobis(2-nitrobenzoic acid). The intensity of the product color, measured at 412 nm, is proportionate to the enzyme activity in the sample.
Price
Catalog Number
$480
LS-K323-100

Available for USA Shipment Only
Toll Free North America
206-374-1102
For Research Use Only

Overview

Description:
ACETYLCHOLINESTERASE (EC 3.1.1.7, AChE), also known as RBC cholinesterase, is found primarily in the blood and neural synapses. AChE catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. Inhibition of the enzyme leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. AChE inhibition is an important target for the management of Alzheimer's disease and AChE inhibitors are the most common drugs used for its management. In addition to Alzheimer's disease, AChE inhibitors have been useful in the diagnosis or treatment of diseases such as glaucoma, myasthenia gravis, bladder distention, and more. BioAssay Systems' QuantiChromTM Acetylcholinesterase Inhibitor Screening kit is based on an improved Ellman method, in which thiocholine produced by the action of acetylcholinesterase forms a yellow color with 5,5'-dithiobis(2-nitrobenzoic acid). The intensity of the product color, measured at 412 nm, is proportionate to the enzyme activity in the sample.

Specifications

Name
Acetylcholinesterase (AChE) Inhibitor Screening Kit (Color)
Type
Inhibitor Screening
Usage
HTS for inhibitor screening and evaluation of acetylcholinesterase inhibitors by a colorimetric (412nm) method.
Target
Acetylcholinesterase
Detection
Colorimetric (412 nm Absorbance)
Supplied Components
The following components are supplied with this product.
  • Assay Buffer (pH 7.5)
  • DTNB
  • Substrate (100mM)
  • (See Datasheet for specific volumes supplied)
Applications
Spectrophotometry (visible)
Equipment
Microplate spectrophotometer (visible)
Conditions
Shipped Ambient, Store at -20°C, 12 months shelf life.
Documents
Restrictions
For research use only. Intended for use by laboratory professionals. Available for shipment within the USA only
Guarantee
This Assay Kit carries the LSBio 100% Guarantee

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Colorimetry

Acetylcholinesterase Assay Kit

Colorimetry

Acetylcholinesterase Assay Kit

Colorimetry

Acetylcholinesterase Assay Kit

Colorimetry

Acetylcholinesterase Assay Kit

Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 7/19/2024