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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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XPO1 / CRM1 Antibody (aa390‑408) IHC‑plus™ LS‑B1776 Best Seller
Note: This antibody replaces LS-C47283, LS-B3183
CRM1 antibody LS-B1776 is an unconjugated rabbit polyclonal antibody to CRM1 (XPO1) from human, bat, bovine and other species. Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-B1776-50
50 µg (0.5 mg/ml)
$425

Popular XPO1 / CRM1 Products

Fetal heart cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 6%-18%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit, Chicken, Xenopus
Applications: Western blot
Anti-XPO1 / CRM1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Immunofluorescence
Anti-XPO1 / CRM1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation, Proximity Ligation Assay
Immunohistochemistry of paraffin-embedded human pancreatic tissue using XPO1 Antibody at dilution of 1:100
Species: Human, Mouse
Applications: IHC, Immunofluorescence, Western blot, ELISA

Product Description

CRM1 antibody LS-B1776 is an unconjugated rabbit polyclonal antibody to CRM1 (XPO1) from human, bat, bovine and other species. Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues.

Specifications

Target
Human XPO1 / CRM1
Synonyms
XPO1, CRM1, yeast, homolog, Exp1, Exportin-1, CRM1
Host
Rabbit
Reactivity
Human, Monkey, Bat, Bovine, Dog, Horse, Chicken, Xenopus (tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat, Hamster, Rabbit, Zebrafish (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • Western blot (1 - 3 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
XPO1 / CRM1 antibody was raised against amino acids 390-408 (ASPLLSGSQHFDVPPRRQL) of human Exportin-1 protein were used as the immunogen. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Bovine, Dog, Bat, Horse, Chicken, Platypus, Xenopus (100%); Mouse, Rat, Hamster, Rabbit, Opossum, Zebrafish (95%); Stickleback, Pufferfish (89%).
Epitope
aa390-408
Specificity
Amino acids 390-408 (ASPLLSGSQHFDVPPRRQL) of human Exportin-1 protein.
Usage
Immunohistochemistry: LS-B1776 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B1776 was determined to be 10 ug/ml.
Presentation
PBS, 0.05% Sodium Azide, 0.2% Gelatin
Storage
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
Restrictions
For research use only.
About XPO1 / CRM1
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. O14980 NM_003400 NP_003391.1


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Images

Immunohistochemistry

Anti-CRM1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CRM1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Immunohistochemistry

Anti-CRM1 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CRM1 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Western blot

Western blot of Exportin-1 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at 1.5 ug/ml.
Western blot of Exportin-1 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at 1.5 ug/ml.

Immunohistochemistry

Anti-CRM1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CRM1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Immunohistochemistry

Anti-CRM1 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CRM1 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Western blot

Western blot of Exportin-1 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at 1.5 ug/ml.
Western blot of Exportin-1 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at 1.5 ug/ml.

Immunohistochemistry

Anti-CRM1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CRM1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Immunohistochemistry

Anti-CRM1 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CRM1 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Western blot

Western blot of Exportin-1 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at 1.5 ug/ml.
Western blot of Exportin-1 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at 1.5 ug/ml.

Immunohistochemistry

Anti-CRM1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CRM1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Immunohistochemistry

Anti-CRM1 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CRM1 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Western blot

Western blot of Exportin-1 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at 1.5 ug/ml.
Western blot of Exportin-1 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at 1.5 ug/ml.

Requested From: United States
Date Requested: 11/13/2018

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