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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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XAF1 Antibody (aa201‑218) LS‑C842
Note: This antibody replaces LS-C18560
XAF1 antibody LS-C842 is an unconjugated rabbit polyclonal antibody to human XAF1. Validated for IHC and WB.
Catalog
Size
Price
LS-C842-100
100 µg (0.5 mg/ml)
$335

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Product Description

XAF1 Antibody (aa201-218) for IHC, WB/Western LS-C842

Specifications

Target
Human XAF1
Synonyms
XAF1, BIRC4 binding protein, BIRC4-binding protein, BIRC4BP, HSXIAPAF1, XIAP-associated factor 1, XIAPAF1, XIAP associated factor 1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC (1:100)
  • Western blot (1 - 2 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
XAF1 antibody was raised against amino acids 201-218 (NQTSTMEKDVRPKTRSIN) and 301-317 (QLDLEKERYYKFKRFHF)of human XAF1, GenBank no. CAA68030.1, were used as immunogen. Percent identity by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (89%).
Epitope
aa201-218
Specificity
In human liver, a 34 kD band should be observed.
Presentation
PBS, 0.02% Sodium Azide
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About XAF1
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. Q6GPH4 NM_017523 NP_059993.2


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Images

Western blot

Western blot of XAF1 in human liver lysates using antibody at 1 ug/ml.
Western blot of XAF1 in human liver lysates using antibody at 1 ug/ml.

Western blot

Western blot of XAF1 in human liver lysates using antibody at 1 ug/ml.
Western blot of XAF1 in human liver lysates using antibody at 1 ug/ml.

Western blot

Western blot of XAF1 in human liver lysates using antibody at 1 ug/ml.
Western blot of XAF1 in human liver lysates using antibody at 1 ug/ml.

Western blot

Western blot of XAF1 in human liver lysates using antibody at 1 ug/ml.
Western blot of XAF1 in human liver lysates using antibody at 1 ug/ml.

Requested From: United States
Date Requested: 10/15/2018

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