WEE1

WEE1 G2 checkpoint kinase

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

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Products

Antibodies (42)

Proteins (5)

ELISA Kits (2)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Over-Expression Lysate (2)

Primary (42)

Recombinant (3)

Target

WEE1 (49)

Reactivity

Human (43)

Mouse (21)

Rat (15)

Ustilago maydis (1)

Application

IHC (18)

IHC-P (3)

WB (34)

ELISA (31)

IF (1)

Peptide-ELISA (3)

Host

rabbit (40)

mouse (1)

goat (1)

Isotype

Ig (1)

IgG (36)

IgM,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (41)

Clone

5B6 (1)

Format

96-Well Microplate (2)

APC Conjugated (3)

Azide-free (3)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (3)

Unconjugated (24)

Epitope

aa144-173 (7)

aa202-230 (7)

aa604-634 (7)

30-110 aa (2)

pSer53 (2)

pSer642 (2)

580-660 aa (1)

C-Terminus (1)

aa19-68 (1)

p53 (1)

Publications

No (49)

Sample Type

Adherent Cell Cultures (2)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

WEE1 Antibody (aa144-173) LS-C101210

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa144-173) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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WEE1 Antibody (clone 5B6) LS-C198441

Antibody:

WEE1 Mouse anti-Human Monoclonal (5B6) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$423

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Mouse/Human/Rat WEE1 (Cell-Based ELISA) ELISA Kit - LS-F2389

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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WEE1 Antibody (aa202-230) LS-C326358

Antibody:

WEE1 Rabbit anti-Mouse Polyclonal (aa202-230) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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WEE1 Antibody (aa604-634) LS-C101209

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa604-634) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

WEE1 Antibody (30-110 aa) LS-C381650

Antibody:

WEE1 Rabbit anti-Human Polyclonal (30-110 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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WEE1 Antibody (phospho-Ser53) LS-C199732

Antibody:

WEE1 Rabbit anti-Human Polyclonal (pSer53) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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WEE1 Antibody (aa19-68) LS-C118328

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa19-68) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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WEE1 Antibody LS-C500311

Antibody:

WEE1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

WEE1 Antibody (aa604-634) LS-C329106

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa604-634) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

WEE1 Antibody (aa604-634, Biotin) LS-C284304

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa604-634) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

WEE1 Antibody (aa604-634, FITC) LS-C284307

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa604-634) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

WEE1 Antibody (aa604-634, APC) LS-C284305

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa604-634) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

WEE1 Antibody (aa604-634, Azide-free, HRP) LS-C284306

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa604-634) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

WEE1 Antibody (aa604-634, PE) LS-C284308

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa604-634) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

WEE1 Antibody (aa144-173) LS-C329107

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa144-173) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

WEE1 Antibody (aa144-173, Biotin) LS-C284309

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa144-173) (Biotin) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

WEE1 Antibody (aa144-173, FITC) LS-C284312

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa144-173) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

WEE1 Antibody (aa144-173, APC) LS-C284310

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa144-173) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

WEE1 Antibody (aa144-173, Azide-free, HRP) LS-C284313

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa144-173) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

WEE1 Antibody (aa144-173, PE) LS-C284314

Antibody:

WEE1 Rabbit anti-Human Polyclonal (aa144-173) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

WEE1 Antibody (phospho-Ser53) LS-C825475

Antibody:

WEE1 Rabbit anti-Human Polyclonal (pSer53) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

WEE1 Antibody LS-C834919

Antibody:

WEE1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

WEE1 Antibody (30-110 aa) LS-C386670

Antibody:

WEE1 Rabbit anti-Human Polyclonal (30-110 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

WEE1 Antibody LS-C136965

Antibody:

WEE1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$332

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