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20700 44th Avenue W
Lynnwood, WA 98036
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USP20 / VDU2
ubiquitin specific peptidase 20
Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
| Gene Name: | ubiquitin specific peptidase 20 |
| Family/Subfamily: | Protease , Cysteine C19 |
| Synonyms: | USP20, Deubiquitinating enzyme 20, Ubiquitin specific protease 20, Ubiquitin thioesterase 20, HVDU2, KIAA1003, LSFR3A, Ubiquitin thiolesterase 20, VDU2 |
| Target Sequences: | NM_006676 NP_006667.3 Q9Y2K6 |
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