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UPK1A / Uroplakin 1A is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene.
Gene Name: | uroplakin 1A |
Family/Subfamily: | Tetraspan , not assigned-Tetraspan |
Synonyms: | UPK1A, UP1A, UPIA, Uroplakin-1a, Tetraspanin-21, Tspan-21, TSPAN21, UPKA, Uroplakin 1A, Uroplakin Ia |
Target Sequences: | NM_007000 NP_008931.1 O00322 |
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