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UNC45B
unc-45 homolog B (C. elegans)
UNC45B is a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants.
| Gene Name: | unc-45 homolog B (C. elegans) |
| Synonyms: | UNC45B, CMYA4, Protein unc-45 homolog B, Unc-45 homolog B (C. elegans), UNC45, SMUNC45, UNC-45B, Cardiomyopathy associated 4, Striated muscle UNC45 |
| Target Sequences: | NP_775259.1 Q8IWX7 |
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