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TRPM4
transient receptor potential cation channel, subfamily M, member 4
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
| Gene Name: | transient receptor potential cation channel, subfamily M, member 4 |
| Family/Subfamily: | Ion Channel , Calcium channel - TRP |
| Synonyms: | TRPM4, HTRPM4, LTrpC-4, PFHB1B, Melastatin-4, TRPM4B, LTrpC4 |
| Target Sequences: | NM_017636 NP_060106.2 Q8TD43 |
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