Human TRF1 / TERF1

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

BED5

Unconjugated

Affinity purified

Unmodified

Recombinant TRF1

Recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kD protein. Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. Reported to work in Western blotting applications.

• IHC
• IHC - Paraffin (10 µg/ml)
• IHC - Frozen
• ELISA

Immunohistochemistry: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose Histology Positive Control Tissue: Human tonsil.

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P54274 NCBI: NM_017489 NP_059523.2