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TRB3 / TRIB3
tribbles pseudokinase 3
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.
| Gene Name: | tribbles pseudokinase 3 |
| Synonyms: | TRIB3, C20orf97, NIPK, SINK, TRB-3, TRB3, DJ1103G7.3, SKIP3, Tribbles homolog 3 |
| Target Sequences: | NM_021158 NP_066981.2 Q96RU7 |
Publications (1)
1
Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics. A Blumental-Perry, R Jobava, I Bederman, A J Degar, H Kenche, B J Guan, K Pandit, N A Perry, N D Molyneaux, J Wu, E Prendergas, Z-W Ye, J Zhang, C E Nelson, F Ahangari, D Krokowski, S H Guttentag, P A Linden, D M Townsend, A Miron, M-J Kang, N Kaminski, Y Perry, M Hatzoglou. Communications biology. 2020 October;3:626. [Full Text Article]
[PubMed:33127975]
[PMC:PMC7603330]
Related Antibodies: LS-C164592.
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TRB3 / TRIB3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
TRB3 / TRIB3 Rabbit anti-Mouse Polyclonal (aa305-334) Antibody
Mouse
WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
Fast Shipping
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Fast Shipping
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (OTI3G4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (OTI3C6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (Carrier-free) (OTI3C6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa112-125) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$323
TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (OTI3F3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (Carrier-free) (OTI3F3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (OTI3F6) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (Carrier-free) (OTI3F6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (OTI1F6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TRB3 / TRIB3 Mouse anti-Human Monoclonal (aa1-200) (Carrier-free) (OTI1F6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
TRB3 / TRIB3 Rabbit anti-Human Polyclonal (aa15-45) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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