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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Phone: 866-819-4732 (Toll Free North America)
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TOPBP1 Antibody (FITC) LS‑C695022
TOPBP1 antibody LS-C695022 is an FITC-conjugated rabbit polyclonal antibody to mouse TOPBP1. Validated for IHC and WB.
Catalog
Size
Price
LS-C695022-20
20 µl
$215
LS-C695022-100
100 µl
$285
LS-C695022-200
200 µl
$335
LS-C695022-1
1 ml
$650
LS-C695022-10
10 ml
$2,580

Popular TOPBP1 Products

Immunohistochemistry - Paraffin Image
Species: Human
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Immunohistochemistry of paraffin-embedded human gastric cancer tissue.
Species: Human, Mouse
Applications: IHC, Immunofluorescence, Western blot
Immunohistochemistry of paraffin-embedded rat lung using TOPBP1 antibody at dilution of 1:100 (40x lens).
Species: Human, Mouse, Rat
Applications: IHC, Western blot
Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.
Species: Human
Applications: IHC, IHC - Paraffin, ELISA
Antibody
Species: Human
Applications: ICC, Western blot

Product Description

TOPBP1 antibody LS-C695022 is an FITC-conjugated rabbit polyclonal antibody to mouse TOPBP1. Validated for IHC and WB.
About TOPBP1
Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR. Q92547 NM_007027 NP_008958.2

TOPBP1 Antibody, KIAA0259 Antibody, TOP2BP1 Antibody


Specifications

Target
Mouse TOPBP1
Host
Rabbit
Reactivity
Mouse (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Fluorescein. Also available Unconjugated or conjugated with Biotin, Cy3, HRP, APC, PE, APC, Cy7.
Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Modifications
Unmodified
Applications
  • IHC
  • Western blot
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
TOPBP1 antibody was raised against tOPBP1, Mouse
Specificity
The antibody is a rabbit polyclonal antibody raised against TOPBP1. It has been selected for its ability to recognize TOPBP1 in immunohistochemical staining and western blotting.
Presentation
PBS, pH 7.4, 0.02% Sodium Azide, 50% Glycerol
Storage
Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months.
Restrictions
For research use only.

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Images

Immunohistochemistry

Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

Western blot

Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

Immunohistochemistry

Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

Western blot

Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

Immunohistochemistry

Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

Western blot

Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

Immunohistochemistry

Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

Western blot

Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

Requested From: United States
Date Requested: 9/23/2018

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