Cardiac Troponin I antibody LS-C42578 is an unconjugated goat polyclonal antibody to human Cardiac Troponin I (TNNI3). Validated for ELISA.
Human TNNI3 / Cardiac Troponin I
(tested or 100% immunogen sequence identity)
Native human cardiac troponin I, purity greater than 98%.
Recognizes human cardiac-specific troponin I, (TnI) an integral inhibitory protein of cardiac muscle which exists as a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin to form a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, and can be used to differentiate between angina and myocardic infarction in patients with chest pain. Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro.
PBS, pH 7.4, 0.09% Sodium Azide
For research use only.
About TNNI3 / Cardiac Troponin I