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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TNNI3 / Cardiac Troponin I Antibody (aa20‑24, clone 22B11) LS‑C58316
Cardiac Troponin I antibody LS-C58316 is an unconjugated mouse monoclonal antibody to human Cardiac Troponin I (TNNI3). Validated for ELISA and WB.
Catalog
Size
Price
LS-C58316-200
200 µg
$385
Description
Cardiac Troponin I antibody LS-C58316 is an unconjugated mouse monoclonal antibody to human Cardiac Troponin I (TNNI3). Validated for ELISA and WB.
Target
Human TNNI3 / Cardiac Troponin I
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2b Monoclonal [22B11]
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • Western blot
  • ELISA
Immunogen
Dephosphorylated form of human cardiac Troponin I.
Epitope
aa20-24
Specificity
Recognizes the dephosphorylated form of human cardiac Troponin I (cTnI). Troponin I is a 24kD subunit of Troponin, a protein found on muscle tissue responsible for muscle contraction. When calcium binds to Troponin C, a conformational change moves Troponin I and tropomyosin out of the way of the myosin binding sites on the actin filaments in muscles. This allows cross-bridging to occur and the muscle to contract. Levels of cTnI in serum are commonly used as a marker for cardiac cell damage and death. Phosphorylation of cTnI results in changes in the activity and function of Troponin. One possible form of phosphorylation is by Protein kinase A. Protein kinase A phosphorylation of serine 22 and serine 23 reduces calcium sensitivity of Troponin and leads to an acceleration in relaxation. Changes in cTnI phosphorylation have been reported in failing hearts. Recognizes the dephosphorylated form of cTnI. Recognizes amino acid residues 20-24 on cTnI. The antibody will recognize free dephosphorylated cTnI or dephosphorylated cTnI in complex with other troponin components. Does not cross react with phosphorylated cTnI or with skeletal TnI.
Presentation
PBS, pH 7.4, 0.09% Sodium Azide
Storage
Short term: -20°C; Long term: -20°C.
Restrictions
For research use only.
About TNNI3 / Cardiac Troponin I
P19429 NM_000363 NP_000354.4

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Requested From: United States
Date Requested: 12/17/2018
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