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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
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TNK1
tyrosine kinase, non-receptor, 1
TNK1 belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | tyrosine kinase, non-receptor, 1 |
| Family/Subfamily: | Protein Kinase , ACK |
| Synonyms: | TNK1, CD38 negative kinase 1 |
| Target Sequences: | NM_003985 NP_003976.2 Q13470 |
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