VEGI antibody LS-C751494 is an unconjugated mouse recombinant monoclonal antibody to human VEGI (TNFSF15 / TL1A). Validated for IHC and PMA.
Human TNFSF15 / TL1A / VEGI
(tested or 100% immunogen sequence identity)
Protein A/G purified
- IHC - Fixed
- Protein Microarray
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Recombinant full-length human VEGI protein. Antigen Molecular Weight: 22 kDa
VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.
Immunohistology (Formalin-fixed - 1-2 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Store at 2°C to 8°C for up to 2 years.
For research use only.
About TNFSF15 / TL1A / VEGI