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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TNFSF15 / TL1A / VEGI Antibody (clone rVEGI/1283) LS‑C751494
VEGI antibody LS-C751494 is an unconjugated mouse recombinant monoclonal antibody to human VEGI (TNFSF15 / TL1A). Validated for IHC and PMA.
Catalog
Size
Price
LS-C751494-20
20 µg (200 µg/ml)
$295
LS-C751494-100
100 µg (200 µg/ml)
$465
Description
VEGI antibody LS-C751494 is an unconjugated mouse recombinant monoclonal antibody to human VEGI (TNFSF15 / TL1A). Validated for IHC and PMA.
Target
Human TNFSF15 / TL1A / VEGI
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Recombinant Monoclonal [rVEGI/1283]
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified
Applications
  • IHC - Fixed
  • Protein Microarray
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Recombinant full-length human VEGI protein. Antigen Molecular Weight: 22 kDa
Specificity
VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.
Usage
Immunohistology (Formalin-fixed - 1-2 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only.
About TNFSF15 / TL1A / VEGI
O95150 NM_005118 NP_005109.2

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Images

Immunohistochemistry - Fixed

Formalin-fixed, paraffin-embedded human Spleen stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).
Formalin-fixed, paraffin-embedded human Spleen stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).

Immunohistochemistry - Fixed

Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).
Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).

Protein Microarray

Analysis of Protein Array containing more than 19,000 full-length human proteins using TNFS15 / VEGI Recombinant Mouse Monoclonal Antibody (rVEGI/1283).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using TNFS15 / VEGI Recombinant Mouse Monoclonal Antibody (rVEGI/1283).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Immunohistochemistry - Fixed

Formalin-fixed, paraffin-embedded human Spleen stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).
Formalin-fixed, paraffin-embedded human Spleen stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).

Immunohistochemistry - Fixed

Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).
Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).

Protein Microarray

Analysis of Protein Array containing more than 19,000 full-length human proteins using TNFS15 / VEGI Recombinant Mouse Monoclonal Antibody (rVEGI/1283).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using TNFS15 / VEGI Recombinant Mouse Monoclonal Antibody (rVEGI/1283).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Immunohistochemistry - Fixed

Formalin-fixed, paraffin-embedded human Spleen stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).
Formalin-fixed, paraffin-embedded human Spleen stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).

Immunohistochemistry - Fixed

Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).
Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).

Protein Microarray

Analysis of Protein Array containing more than 19,000 full-length human proteins using TNFS15 / VEGI Recombinant Mouse Monoclonal Antibody (rVEGI/1283).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using TNFS15 / VEGI Recombinant Mouse Monoclonal Antibody (rVEGI/1283).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Immunohistochemistry - Fixed

Formalin-fixed, paraffin-embedded human Spleen stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).
Formalin-fixed, paraffin-embedded human Spleen stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).

Immunohistochemistry - Fixed

Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).
Formalin-fixed, paraffin-embedded human Parathyroid Mass stained with TNFS15 / VEGI Monoclonal Antibody (rVEGI /1283).

Protein Microarray

Analysis of Protein Array containing more than 19,000 full-length human proteins using TNFS15 / VEGI Recombinant Mouse Monoclonal Antibody (rVEGI/1283).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using TNFS15 / VEGI Recombinant Mouse Monoclonal Antibody (rVEGI/1283).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Requested From: United States
Date Requested: 12/11/2018
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