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TM4SF6 / TSPAN6
tetraspanin 6
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing.
| Gene Name: | tetraspanin 6 |
| Family/Subfamily: | Tetraspan , not assigned-Tetraspan |
| Synonyms: | TSPAN6, A15 homolog, Tetraspanin TM4-D, Tetraspanin-6, TM4SF6, Tetraspanin 6, T245, T245 protein, Tetraspan TM4SF, TSPAN-6 |
| Target Sequences: | NM_003270 NP_003261.1 O43657 |
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