TLR4

toll-like receptor 4

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

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Antibodies (166)

ELISA Kits (28)

Proteins (16)

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Competitive EIA (2)

Development Kit (3)

Over-Expression Lysate (2)

Primary (166)

Recombinant (14)

Sandwich (20)

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TLR4 (210)

Reactivity

Human (142)

Mouse (70)

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PathPlus™ TLR4 Antibody (aa100-200, clone 76B357.1) LS-B2070

Neuroscience

(5.0) Rating

(2) Publication(s)

Antibody:

TLR4 Mouse anti-Human Monoclonal (aa100-200) (76B357.1) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ TLR4 Antibody (clone 1E11) LS-B2254

(5.0) Rating

(1) Publication(s)

Antibody:

TLR4 Mouse anti-Human Monoclonal (1E11) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$485

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PathPlus™ TLR4 Antibody (Internal) LS-A9704

Neuroscience

Fast Shipping

(5.0) Rating

Antibody:

TLR4 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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TLR4 Antibody (clone HTA125) LS-C40824

(4.0) Rating

(1) Publication(s)

Antibody:

TLR4 Mouse anti-Human Monoclonal (HTA125) Antibody

Reactivity:

Guinea pig, Human

Applications:

Flo, IF, IHC, IHC-Fr

Format:

Unconjugated

Price:

100 µg/$339

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TLR4 Antibody LS-C180173

(4.0) Rating

(1) Publication(s)

Antibody:

TLR4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 ml/$386

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IHC-plus™ TLR4 Antibody (aa650-700) LS-B8675

(4.0) Rating

Antibody:

TLR4 Rabbit anti-Human Polyclonal (aa650-700) Antibody

Reactivity:

Bovine, Horse, Macaque, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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PathPlus™ TLR4 Antibody LS-B4696

Neuroscience

(5.0) Rating

Antibody:

TLR4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$440

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TLR4 Antibody (aa161-192) LS-C187853

Antibody:

TLR4 Goat anti-Human Polyclonal (aa161-192) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 mg/$500

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TLR4 Antibody (clone HTA125, FITC) LS-C44225

Antibody:

TLR4 Mouse anti-Human Monoclonal (FITC) (HTA125) Antibody

Reactivity:

Human

Applications:

Flo

Format:

FITC Conjugated

Price:

25 µg/$281; 0.1 mg/$432

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TLR4 Antibody (aa400-450) LS-C359241

Antibody:

TLR4 Rabbit anti-Mouse Polyclonal (aa400-450) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 ml/$386

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IHC-plus™ TLR4 Antibody (aa421-470) LS-B14142

(4.0) Rating

Antibody:

TLR4 Rabbit anti-Human Polyclonal (aa421-470) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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TLR4 Antibody (aa418-435) LS-C756

Antibody:

TLR4 Rabbit anti-Human Polyclonal (aa418-435) Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

ICC, IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

0.1 mg/$386

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TLR4 Antibody (clone HTA125) LS-C546

Antibody:

TLR4 Mouse anti-Human Monoclonal (HTA125) Antibody

Reactivity:

Human

Applications:

Flo, ICC, IP, Neut

Format:

Unconjugated

Price:

0.1 mg/$386

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Mouse TLR4 Protein (Recombinant 6His, N-terminus) (aa26-638) - LS-G57270

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Pig TLR4 (Sandwich ELISA) ELISA Kit - LS-F15158

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse TLR4 Protein (Recombinant His, N-Terminal) (aa26-269) - LS-G12764

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

33.3 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Rat TLR4 (Sandwich ELISA) ELISA Kit - LS-F22360

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.31 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse TLR4 (Sandwich ELISA) ELISA Kit - LS-F21475

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human TLR4 (CLIA) ELISA Kit - LS-F29972

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$863

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Human TLR4 (Sandwich ELISA) ELISA Kit - LS-F3675

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.41 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$700

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Bovine TLR4 (Sandwich ELISA) ELISA Kit - LS-F15159

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Bovine

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Select

Rat TLR4 (Sandwich ELISA) ELISA Kit - LS-F35042

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$768

Select

Human TLR4 (Sandwich ELISA) ELISA Kit - LS-F4447

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$764

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TLR4 Antibody (aa100-200, clone 76B357.1, Azide-free) LS-C367232

Antibody:

TLR4 Mouse anti-Human Monoclonal (aa100-200) (Azide-free) (76B357.1) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Flo, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated, Azide-free

Price:

0.1 mg/$386

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TLR4 Antibody LS-C430

Antibody:

TLR4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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