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TLR3
toll-like receptor 3
TLR3 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
| Gene Name: | toll-like receptor 3 |
| Family/Subfamily: | Toll-like Receptor , not assigned-Toll-like Receptor |
| Synonyms: | TLR3, CD283, Toll-like receptor 3, CD283 antigen, IIAE2 |
| Target Sequences: | NM_003265 NP_003256.1 O15455 |
Publications (6)
1
Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR. Journal of virology. 2008 82:7613-23.
[PubMed:18508883]
[PMC:PMC2493309]
Related Antibodies: LS-C40786.
2
KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation. Sharma NR, Majerciak V, Kruhlak MJ, Zheng ZM. PLoS pathogens. 2017 13:e1006677. (WB; Human)
[Full Text Article]
[PubMed:29084250]
Related Antibodies: LS-C19344.
3
A comparison of the impact of Shimen and C strains of classical swine fever virus on Toll-like receptor expression. Cao Z, Guo K, Zheng M, Ning P, Li H, Kang K, Lin Z, Zhang C, Liang W, Zhang Y. The Journal of general virology. 2015 96:1732-45. (WB; Human)
[Full Text Article]
[PubMed:25805409]
Related Antibodies: LS-C545.
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(151)
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(98)
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(64)
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(6)
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(28)
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(6)
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(11)
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(94)
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(30)
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(1)
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(148)
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(3)
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(2)
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(3)
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(4)
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(1)
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(5)
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(2)
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(1)
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Purified
(3)
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Low endotoxin level
(2)
Biologically Active
Biologically active
(1)
TLR3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
TLR3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TLR3 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
TLR3 Rat anti-Mouse Monoclonal (aa180-385) (ABM24E5) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TLR3 Mouse anti-Human Monoclonal (40C1285.6) Antibody
Goat, Sheep, Human, Monkey
Flo, IHC, IHC-P, IP, WB
Unconjugated
0.1 mg/$386
TLR3 Mouse anti-Human Monoclonal (TLR-104) Antibody
Human
Flo, WB
Unconjugated
100 µg/$401
![TLR3 Antibody - Western Blot: TLR3 Antibody (27N3D4) [Azide Free] - Analysis of TLR3 using TLR3 monoclonal antibody. Human intestine (A), human spleen (B), and mouse RAW lysate probed with TLR3 antibody at 2 ug/ml. Goat anti-rat Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. This image was taken for the unmodified form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/tlr3-antibody-aa350-375-clone-27n3d4-azide-free-ls-c368161/257619_1943912.jpg)
TLR3 Rat anti-Mouse Monoclonal (aa350-375) (Azide-free) (27N3D4) Antibody
Mouse, Human
Flo, WB
Unconjugated, Azide-free
0.1 mg/$386
TLR3 Rabbit anti-Human Polyclonal (pTyr759) Antibody
Human
IF, IHC, IHC-Fr, WB
Unconjugated
20 µg/$386
TLR3 Mouse anti-Human Monoclonal (FITC) (TLR3.7) Antibody
Mouse, Dog, Human
Flo, Func, IF, IHC, IHC-Fr, IHC-P, IP, WB
FITC Conjugated
100 µg/$571
TLR3 Rabbit anti-Mouse Polyclonal (aa135-150) Antibody
Mouse
Flo, IHC, IHC-Fr, WB
Unconjugated
0.1 mg/$386
TLR3 Rat anti-Mouse Monoclonal (aa340-390) (27N3D4) Antibody
Mouse, Human
Flo, WB
Unconjugated
0.1 mg/$386
TLR3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
HEK 293 Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
77.4 kDa
5 µg/$268; 25 µg/$349
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$818
TLR3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TLR3 Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo, WB
PE Conjugated
100 µg/$815
TLR3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC-Fr, WB
Unconjugated
0.1 mg/$470
TLR3 Mouse anti-Human Monoclonal (aa55-85) (Azide-free) (40C1285.6) Antibody
Mouse, Dog, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated, Azide-free
0.1 mg/$386
TLR3 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo
FITC Conjugated
25 µg/$288; 100 µg/$414
TLR3 Mouse anti-Human Monoclonal (Biotin) (40C1285.6) Antibody
Mouse, Dog, Human
ELISA
Biotin Conjugated
0.1 ml/$416
TLR3 Mouse anti-Human Monoclonal (Low Endotoxin) Antibody
Mouse, Canine, Human
Flo, Func, IF, IHC, IHC-Fr, IHC-P, IP
Unconjugated, Low Endotoxin
100 µg/$516
TLR3 Mouse anti-Human Monoclonal (Biotin) (TLR3.7) Antibody
Mouse, Dog, Human
Flo, Func, IF, IHC, IHC-Fr, IHC-P, IP, WB
Biotin Conjugated
50 µg/$429
TLR3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
TLR3 Mouse anti-Human Monoclonal (6F3G4) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
E. coli
His-GST
53.4 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
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