Bovine TGF Beta 1+2+3

Mouse

Bovine, Human, Monkey, Mouse, Rat, Dog, Hamster (tested or 100% immunogen sequence identity)

IgG1,k Monoclonal

1D11.16.8

Unconjugated

Protein G purified

Unmodified. Also available Azide-free, BSA-free.

Bovine TGF-beta2 protein.

Bovine TGF Beta 1+2+3

• Functional Assay

This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80% identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells. Optimal dilution of the TGF-beta antibody should be determined by the researcher.

1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide

Store at 2°C to 8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.