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TFAP2A / AP-2
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. Caution: AP-2B refers to both an alternatively spliced form of AP-2 and to the related transcription factor AP-2 beta.
| Gene Name: | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| Synonyms: | TFAP2A, Activator protein 2, AP-2, AP-2a, AP2TF, AP-2alpha, BOFS, TFAP2, Transcription factor AP-2, AP-2 transcription factor, AP2-alpha |
| Target Sequences: | NM_003220 NP_003211.1 P05549 |
Publications (4)
1
Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2. Zarelli VE, Dawid IB. Proceedings of the National Academy of Sciences of the United States of America. 2013 110:2870-5. (WB, IP; Zebrafish)
[Full Text Article]
[PubMed:23382213]
Related Antibodies: LS-C87212.
2
Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2a and arid3a. Khedgikar V, Abbruzzese G, Mathavan K, Szydlo H, Cousin H, Alfandari D. eLife. 2017 6: (WB; Human)
[Full Text Article]
[PubMed:28829038]
[PMC:PMC5601995]
3
Tfap2a is a novel gatekeeper of nephron differentiation during kidney development. Brooke E Chambers, Gary F Gerlach, Eleanor G Clark, Karen H Chen, Anna E Levesque, Ignaty Leshchiner, Wolfram Goessling, Rebecca A Wingert. Development (Cambridge, England). 2019 July;146: [Full Text Article]
[PubMed:31160420]
[PMC:PMC6633607]
Related Antibodies: LS-C87212.
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(33)
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TFAP2A / AP-2
(42)
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(41)
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(1)
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(2)
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(1)
TFAP2A / AP-2 Goat anti-Zebrafish Polyclonal (aa405-419) Antibody
Zebrafish
Peptide-ELISA
Unconjugated
100 µg/$401
TFAP2A / AP-2 Goat anti-Human Polyclonal (aa1-25) Antibody
Chicken, Mouse, Dog, Rat, Chimpanzee, Orangutan, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$515
Neuroscience
TFAP2A / AP-2 Mouse anti-Human Monoclonal (2G5) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
TFAP2A / AP-2 Mouse anti-Human Monoclonal (2H9B5) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µl/$459
TFAP2A / AP-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TFAP2A / AP-2 Mouse anti-Human Monoclonal (2H9F12) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
TFAP2A / AP-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$688
Wheat Germ Extract
GST
74.5 kDa
10 µg/$479; 25 µg/$670
TFAP2A / AP-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
TFAP2A / AP-2 Mouse anti-Human Monoclonal (959C2a) Antibody
Mouse, Human
DB, Flo, WB
Unconjugated
100 µg/$965
TFAP2A / AP-2 Mouse anti-Human Monoclonal (959C2a) Antibody
Mouse, Human
DB, Flo, WB
Unconjugated
100 µg/$486
TFAP2A / AP-2 Mouse anti-Human Monoclonal (1A10C5) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
TFAP2A / AP-2 Mouse anti-Human Monoclonal (7D2B5) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
TFAP2A / AP-2 Rabbit anti-Human Polyclonal (aa407-436) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
TFAP2A / AP-2 Rabbit anti-Human Polyclonal (aa407-436) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
TFAP2A / AP-2 Rabbit anti-Human Polyclonal (aa407-436) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
TFAP2A / AP-2 Rabbit anti-Human Polyclonal (aa407-436) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
TFAP2A / AP-2 Rabbit anti-Human Polyclonal (aa407-436) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
TFAP2A / AP-2 Rabbit anti-Human Polyclonal (aa407-436) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
TFAP2A / AP-2 Mouse anti-Human Monoclonal Antibody
Mouse, Human
WB
Unconjugated
100 µg/$786
TFAP2A / AP-2 Rabbit anti-Mouse Polyclonal (aa134-166) Antibody
Mouse
WB
Unconjugated
400 µl/$393
TFAP2A / AP-2 Rabbit anti-Human Polyclonal (aa407-436) Antibody
Human
WB
Unconjugated
400 µl/$393
TFAP2A / AP-2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$397
TFAP2A / AP-2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
TFAP2A / AP-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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of 42
product results
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