TDG / Thymine DNA Glycosylase

thymine-DNA glycosylase

DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.

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Products

Antibodies (23)

Proteins (5)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (23)

Recombinant (3)

Sandwich (1)

Target

TDG / Thymine DNA Glycosylase (29)

Reactivity

Human (22)

Mouse (15)

Rat (11)

Bovine (1)

Application

IHC (8)

IHC-P (1)

WB (22)

Flo (2)

ELISA (6)

ICC (1)

IF (6)

IP (2)

Peptide-ELISA (2)

Host

rabbit (18)

mouse (5)

Isotype

IgG (13)

IgG1 (4)

IgG1,k (1)

Clonality

monoclonal mc (5)

polyclonal pc (18)

Clone

AT2F7 (1)

OTI3A12 (2)

OTI3C11 (2)

Format

96-Well Strip Plate (1)

Carrier-free (2)

Unconjugated (23)

Epitope

aa160-253 (4)

aa141-410 (2)

1-80 aa, Internal (1)

Internal (1)

Lys90 (1)

aa281-310 (1)

aa31-80 (1)

aa360-410 (1)

aa81-110 (1)

Publications

No (29)

Sample Type

Tissue Homogenates (1)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

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TDG / Thymine DNA Glycosylase Antibody (Internal) LS-C354097

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$299

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Human TDG / Thymine DNA Glycosylase Protein (Recombinant His) - LS-G1923

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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TDG / Thymine DNA Glycosylase Antibody (aa141-410) LS-C377570

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal (aa141-410) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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TDG / Thymine DNA Glycosylase Antibody (1-80 aa, Internal) LS-C386361

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal (1-80 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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Human TDG / Thymine DNA Glycosylase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81623

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.9 kDa

Price:

20 µg/$150

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TDG / Thymine DNA Glycosylase Antibody (aa160-253, clone OTI3C11) LS-C799021

Antibody:

TDG / Thymine DNA Glycosylase Mouse anti-Human Monoclonal (aa160-253) (OTI3C11) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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TDG / Thymine DNA Glycosylase Antibody (aa160-253, clone OTI3C11, Carrier-free) LS-C791714

Antibody:

TDG / Thymine DNA Glycosylase Mouse anti-Human Monoclonal (aa160-253) (Carrier-free) (OTI3C11) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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TDG / Thymine DNA Glycosylase Antibody (aa160-253, clone OTI3A12) LS-C794395

Antibody:

TDG / Thymine DNA Glycosylase Mouse anti-Human Monoclonal (aa160-253) (OTI3A12) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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TDG / Thymine DNA Glycosylase Antibody (aa160-253, clone OTI3A12, Carrier-free) LS-C791676

Antibody:

TDG / Thymine DNA Glycosylase Mouse anti-Human Monoclonal (aa160-253) (Carrier-free) (OTI3A12) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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TDG / Thymine DNA Glycosylase Antibody (Lys90) LS-C176808

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal (Lys90) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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TDG / Thymine DNA Glycosylase Antibody (aa360-410) LS-C291004

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal (aa360-410) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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TDG / Thymine DNA Glycosylase Antibody LS-C801330

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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TDG / Thymine DNA Glycosylase Antibody LS-C660952

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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TDG / Thymine DNA Glycosylase Antibody LS-C748418

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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TDG / Thymine DNA Glycosylase Antibody (clone AT2F7) LS-C200834

Antibody:

TDG / Thymine DNA Glycosylase Mouse anti-Human Monoclonal (AT2F7) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$303; 100 µl/$365

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TDG / Thymine DNA Glycosylase Antibody (aa81-110) LS-C99357

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal (aa81-110) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

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TDG / Thymine DNA Glycosylase Antibody (aa281-310) LS-C99358

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal (aa281-310) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

TDG / Thymine DNA Glycosylase Antibody LS-C822911

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

TDG / Thymine DNA Glycosylase Antibody (aa141-410) LS-C377568

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal (aa141-410) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

TDG / Thymine DNA Glycosylase Antibody (aa31-80) LS-C119026

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal (aa31-80) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

TDG / Thymine DNA Glycosylase Antibody LS-C833094

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

TDG / Thymine DNA Glycosylase Antibody LS-C771097

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

TDG / Thymine DNA Glycosylase Antibody LS-C417034

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

TDG / Thymine DNA Glycosylase Antibody LS-C335140

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

TDG / Thymine DNA Glycosylase Antibody LS-C334266

Antibody:

TDG / Thymine DNA Glycosylase Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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