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TCEB1 / Elongin C
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
SIII / TCEB1 is the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.
| Gene Name: | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) |
| Synonyms: | TCEB1, Elongin 15 kDa subunit, EloC, SIII, SIII p15, Elongin-C |
| Target Sequences: | NM_005648 NP_005639.1 Q15369 |
Publications (3)
1
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. Maine GN, Mao X, Komarck CM, Burstein E. The EMBO journal. 2007 26:436-47.
[PubMed:17183367]
[PMC:PMC1783443]
2
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. Mao X, Gluck N, Li D, Maine GN, Li H, Zaidi IW, Repaka A, Mayo MW, Burstein E. Genes & development. 2009 23:849-61.
[PubMed:19339690]
[PMC:PMC2666342]
3
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine GN, Burstein E. The Journal of biological chemistry. 2011 286:32355-65.
[PubMed:21778237]
[PMC:PMC3173175]
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His
100 µg/$361; 500 µg/$739; 20 µg/$261
TCEB1 / Elongin C Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
TCEB1 / Elongin C Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (aa69-98) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (aa69-98) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (aa69-98) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (aa69-98) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (aa69-98) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (aa69-98) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
TCEB1 / Elongin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TCEB1 / Elongin C Chicken anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
1 mg/$461
TCEB1 / Elongin C Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IHC, WB
Unconjugated
10 µl/$295; 100 µl/$514
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (aa69-98) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
TCEB1 / Elongin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TCEB1 / Elongin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TCEB1 / Elongin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TCEB1 / Elongin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
TCEB1 / Elongin C Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (aa34-83) Antibody
Human
WB
Unconjugated
100 µl/$424
TCEB1 / Elongin C Rabbit anti-Human Polyclonal (aa53-102) Antibody
Human
WB
Unconjugated
100 µl/$397
TCEB1 / Elongin C Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
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