Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
TAX1BP1, CALCOCO3, T6BP, Tax1-binding protein 1, TRAF6-binding protein, TXBP151
Human, Monkey, Bovine
(tested or 100% immunogen sequence identity)
Mouse, Rat, Bat, Dog, Hamster, Horse, Pig, Rabbit, Chicken (at least 90% immunogen sequence identity)
Protein G purified
Western blot (2 µg/ml)
TAX1BP1 antibody was raised against this antibody was developed against amino acids 718-735 (CSEQFPPDYDQQVFERHV)of human Traf6BP. The sequence used is 94% homologous in mouse. Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Bovine (100%); Mouse, Rat, Dog, Bat, Hamster, Panda, Horse, Rabbit, Pig, Opossum, Turkey, Chicken (94%); Elephant, Platypus (89%); Xenopus, Pufferfish (83%).
There are multiple isoforms of TRAF6BP ranging from 590 amino acids to 858 amino acids. Researchers are encouraged to titer for their specific applications.
PBS, 0.05% Sodium Azide, 0.2% Gelatin
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
TAX1BP1 is a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.