Human SYK

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

SYK-01

Unconjugated

Protein A purified

Unmodified

Recombinant fragment corresponding to aa 5-360 of human Syk.

aa5-360

Recognizes protein tyrosine kinase p72syk (syk), a 72kD non-receptor tyrosine kinase, critical for immunoreceptor signaling in hematopoietic cells, but also expressed by nonhematopoietic cells, including fibroblasts, endothelial cells and hepatocytes. Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways. Further studies have shown that syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and hematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation.

• IHC
• IHC - Paraffin (10 µg/ml)
• Western blot
• Immunoprecipitation

Western Blot: Detects a band of approximately 72kD in Ramos and RBL cell lysates.

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze/thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P43405 NCBI: NM_003177 NP_003168.2