Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Mouse, Bat, Bovine, Dog, Hamster, Horse, Pig, Sheep
(tested or 100% immunogen sequence identity)
Monkey, Rat, Rabbit (at least 90% immunogen sequence identity)
Protein G purified
Western blot (1 - 2 µg/ml)
IHC - Paraffin
STAT1 antibody was raised against a synthetic peptide sequence corresponding to amino acids 711-730 EVHPSRLQTTDNLLPMSPEE of human Stat1, GenBank no. NP_009330.1. This sequence is 100% conserved between Stat1 alpha and Stat1 beta. Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Mouse, Sheep, Hamster, Panda, Bovine, Dog, Bat, Horse, Pig (100%); Marmoset, Elephant (95%); Rat, Rabbit (90%); Opossum, Turkey, Chicken, Xenopus (85%).
This is able to detect both the alpha form (p91, ~91 kD) and the beta form (p84, ~84 kD) of STAT1.
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2.