SMC1A / SMC1

structural maintenance of chromosomes 1A

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Products

Antibodies (80)

ELISA Kits (3)

Proteins (3)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Over-Expression Lysate (2)

Primary (80)

Recombinant (1)

Target

SMC1A / SMC1 (86)

Reactivity

Human (81)

Mouse (56)

Rat (16)

Bat (3)

Bovine (5)

Chicken (3)

Chimpanzee (3)

Dog (4)

Gibbon (3)

Guinea pig (3)

Hamster (3)

Horse (3)

Monkey (4)

Pig (5)

Rabbit (4)

Xenopus (1)

Zebrafish (3)

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Application

IHC (43)

IHC-P (13)

WB (75)

Flo (6)

ELISA (21)

ICC (5)

IF (12)

IHC-IF (1)

IP (8)

Peptide-ELISA (5)

Host

rabbit (47)

mouse (31)

goat (2)

Product Group

PathPlus Neuro (5)

Isotype

IgG (40)

IgG1 (20)

IgG1,k (1)

IgG2b (4)

Clonality

monoclonal mc (31)

polyclonal pc (48)

recombinant monoclonal rmc (1)

Clone

1B9 (1)

5B6 (1)

OTI11E1 (2)

OTI1C5 (2)

OTI2D12 (2)

OTI3G4 (2)

OTI5A1 (2)

OTI5C8 (1)

OTI6C5 (2)

Format

96-Well Microplate (3)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (3)

Carrier-free (6)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (67)

Epitope

pSer957 (16)

aa889-1016 (13)

aa307-336 (7)

C-Terminus (5)

pSer966 (4)

900-980 aa (2)

N-Terminus (2)

aa1175-C-term (2)

910-990 aa (1)

Ser360 (1)

Ser951 (1)

aa1-130 (1)

aa1-248 (1)

aa1183-1233 (1)

aa931-980 (1)

p957 (1)

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Publications

No (86)

Sample Type

Adherent Cell Cultures (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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PathPlus™ SMC1A / SMC1 Antibody (clone 1B9) LS-B5432

Neuroscience

(5.0) Rating

Antibody:

SMC1A / SMC1 Mouse anti-Human Monoclonal (1B9) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$440

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Mouse/Human SMC1A / SMC1 (Cell-Based ELISA) ELISA Kit - LS-F2316

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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PathPlus™ SMC1A / SMC1 Antibody LS-B16479

Neuroscience

(5.0) Rating

Antibody:

SMC1A / SMC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Xenopus, Mouse, Human

Applications:

IF, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$485

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SMC1A / SMC1 Antibody LS-C812775

Antibody:

SMC1A / SMC1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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SMC1A / SMC1 Antibody (clone 5B6) LS-C169196

Antibody:

SMC1A / SMC1 Mouse anti-Human Monoclonal (5B6) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$435

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SMC1A / SMC1 Antibody (phospho-Ser966) LS-C286995

Antibody:

SMC1A / SMC1 Rabbit anti-Human Polyclonal (pSer966) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$533

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PathPlus™ SMC1A / SMC1 Antibody (aa1175-C-term) LS-B11277

Neuroscience

(5.0) Rating

Antibody:

SMC1A / SMC1 Rabbit anti-Human Polyclonal (aa1175-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

SMC1A / SMC1 Antibody (phospho-Ser957) LS-C801187

Antibody:

SMC1A / SMC1 Rabbit anti-Human Polyclonal (pSer957) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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SMC1A / SMC1 Antibody (N-Terminus) LS-C178300

Antibody:

SMC1A / SMC1 Mouse anti-Human Monoclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Pig, Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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SMC1A / SMC1 Antibody LS-C393492

Antibody:

SMC1A / SMC1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$391

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SMC1A / SMC1 Antibody LS-C755051

Antibody:

SMC1A / SMC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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SMC1A / SMC1 Antibody LS-C801641

Antibody:

SMC1A / SMC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

PathPlus™ SMC1A / SMC1 Antibody (aa1175-C-term) LS-B11029

Neuroscience

(5.0) Rating

Antibody:

SMC1A / SMC1 Rabbit anti-Human Polyclonal (aa1175-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$460

Select

SMC1A / SMC1 Antibody LS-C836100

Antibody:

SMC1A / SMC1 Rabbit Recombinant Monoclonal Antibody

Applications:

Flo, ICC, IHC, IHC-IF, IP, WB

Format:

Unconjugated

Price:

20 µl/$299; 100 µl/$425

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PathPlus™ SMC1A / SMC1 Antibody (aa1-248) LS-B16485

Neuroscience

(5.0) Rating

Antibody:

SMC1A / SMC1 Rabbit anti-Human Polyclonal (aa1-248) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

SMC1A / SMC1 Antibody LS-C813120

Antibody:

SMC1A / SMC1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Pig, Human

Applications:

Flo, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$406; 200 µg/$505

Select

SMC1A / SMC1 Antibody (phospho-Ser957) LS-C335779

Antibody:

SMC1A / SMC1 Rabbit anti-Human Polyclonal (pSer957) Antibody

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539

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SMC1A / SMC1 Antibody (aa1-130) LS-C377390

Antibody:

SMC1A / SMC1 Rabbit anti-Human Polyclonal (aa1-130) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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Mouse/Human/Rat Phospho-SMC1A / SMC1 (Ser966) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1221

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

SMC1A / SMC1 Antibody (aa889-1016, clone OTI2D12) LS-C799046

Antibody:

SMC1A / SMC1 Mouse anti-Human Monoclonal (aa889-1016) (OTI2D12) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

SMC1A / SMC1 Antibody (aa889-1016, clone OTI2D12, Carrier-free) LS-C792236

Antibody:

SMC1A / SMC1 Mouse anti-Human Monoclonal (aa889-1016) (Carrier-free) (OTI2D12) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SMC1A / SMC1 Antibody (aa889-1016, clone OTI11E1, Carrier-free) LS-C798726

Antibody:

SMC1A / SMC1 Mouse anti-Human Monoclonal (aa889-1016) (Carrier-free) (OTI11E1) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

Select

SMC1A / SMC1 Antibody (aa889-1016, clone OTI3G4) LS-C795149

Antibody:

SMC1A / SMC1 Mouse anti-Human Monoclonal (aa889-1016) (OTI3G4) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

SMC1A / SMC1 Antibody (aa889-1016, clone OTI3G4, Carrier-free) LS-C799662

Antibody:

SMC1A / SMC1 Mouse anti-Human Monoclonal (aa889-1016) (Carrier-free) (OTI3G4) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

SMC1A / SMC1 Antibody (aa889-1016, clone OTI5A1, Carrier-free) LS-C792228

Antibody:

SMC1A / SMC1 Mouse anti-Human Monoclonal (aa889-1016) (Carrier-free) (OTI5A1) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

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