SMARCC2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

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Products

Antibodies (17)

Proteins (6)

ELISA Kits (2)

Type

Cell-Based (1)

DNA Binding (1)

Over-Expression Lysate (4)

Primary (17)

Recombinant (2)

Target

SMARCC2 (25)

Reactivity

Human (19)

Mouse (14)

Rat (3)

Bat (3)

Bovine (3)

Chimpanzee (3)

Gibbon (3)

Horse (3)

Monkey (3)

Pig (3)

Rabbit (3)

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Application

IHC (6)

IHC-P (3)

WB (16)

ChrIP (1)

ELISA (4)

ICC (1)

IF (5)

IP (2)

Peptide-ELISA (2)

Host

rabbit (17)

Isotype

IgG (11)

Clonality

polyclonal pc (17)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (14)

Epitope

aa254-303 (4)

aa1164-C-term (2)

330-410 aa, Internal (1)

Internal (1)

Met388 (1)

aa300-650 (1)

aa361-410 (1)

aa575-625 (1)

Publications

No (25)

Sample Type

Adherent Cell Cultures (1)

Cell Lysates (1)

Nuclear Lysates (1)

Tag

GST (1)

Myc-DDK (Flag) (5)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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SMARCC2 Antibody (aa1164-C-term) LS-C287869

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal (aa1164-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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SMARCC2 Antibody (aa300-650) LS-C378925

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal (aa300-650) Antibody

Reactivity:

Mouse, Human

Applications:

ChrIP, ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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SMARCC2 Antibody LS-C660489

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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SMARCC2 Antibody (Internal) LS-C354078

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$299

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SMARCC2 Antibody (330-410 aa, Internal) LS-C382226

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal (330-410 aa, Internal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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SMARCC2 Antibody LS-C331791

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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SMARCC2 Antibody LS-C809282

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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SMARCC2 Antibody LS-C770727

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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SMARCC2 Antibody (Met388) LS-C176824

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal (Met388) Antibody

Reactivity:

Mouse, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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SMARCC2 Antibody (aa1164-C-term) LS-C286461

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal (aa1164-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

1 µg/$295; 100 µl/$532

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SMARCC2 Antibody LS-C823086

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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SMARCC2 Antibody (aa575-625) LS-C287878

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal (aa575-625) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

SMARCC2 Antibody (aa361-410) LS-C119160

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal (aa361-410) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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SMARCC2 Antibody (aa254-303) LS-C206181

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal (aa254-303) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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SMARCC2 Antibody (aa254-303, HRP) LS-C479687

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal (aa254-303) (HRP) Antibody

Reactivity:

Rabbit, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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SMARCC2 Antibody (aa254-303, Biotin) LS-C479685

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal (aa254-303) (Biotin) Antibody

Reactivity:

Rabbit, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SMARCC2 Antibody (aa254-303, FITC) LS-C479686

Antibody:

SMARCC2 Rabbit anti-Human Polyclonal (aa254-303) (FITC) Antibody

Reactivity:

Rabbit, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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Human SMARCC2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68239

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

124.7 kDa

Price:

20 µg/$1,107

Select

Human SMARCC2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81722

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

132.7 kDa

Price:

20 µg/$150

Select

Human SMARCC2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81724

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

124.7 kDa

Price:

20 µg/$150

Select

Human SMARCC2 Protein (Recombinant GST) (Full Length) - LS-G30460

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

149.93 kDa

Price:

2 µg/$439

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SMARCC2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107121

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

124.7 kDa

Price:

100 µg/$494

Select

Mouse/Human SMARCC2 (DNA-Binding ELISA) ELISA Kit - LS-F934

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$694

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Mouse/Human SMARCC2 (Cell-Based ELISA) ELISA Kit - LS-F3260

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

Select

SMARCC2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117571

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

132.7 kDa

Price:

100 µg/$494

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