SMAD7

SMAD family member 7

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

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Products

Antibodies (31)

ELISA Kits (20)

Proteins (3)

Type

Custom (1)

Over-Expression Lysate (1)

Primary (31)

Recombinant (2)

Sandwich (18)

Sandwich CLIA (1)

Target

SMAD7 (54)

Reactivity

Human (36)

Mouse (17)

Rat (24)

Bat (2)

Bovine (3)

Chicken (1)

Dog (2)

Guinea pig (1)

Monkey (9)

Pig (2)

Porcine (1)

Rabbit (1)

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Application

IHC (8)

IHC-P (4)

WB (28)

ELISA (5)

IF (4)

Peptide-ELISA (1)

Host

rabbit (30)

mouse (1)

Product Group

IHCPlus (2)

Isotype

IgG (24)

IgG2b (1)

Clonality

monoclonal mc (1)

polyclonal pc (30)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (3)

96-Well Strip Plate (16)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

Preservative Free (1)

Unconjugated (25)

Epitope

N-Terminus (4)

aa24-73 (4)

Internal (2)

aa12-18 (1)

aa12-29 (1)

aa230-426 (1)

aa320-398 (1)

aa36-50 (1)

aa49-317 (1)

Publications

No (54)

Sample Type

Cell Lysates (3)

Plasma (12)

Serum (12)

Tissue Homogenates (6)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

HEK 293 Cells (2)

Wheat Germ Extract (1)

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IHC-plus™ SMAD7 Antibody (aa36-50) LS-B120

(4.0) Rating

Antibody:

SMAD7 Rabbit anti-Human Polyclonal (aa36-50) Antibody

Reactivity:

Dog, Bovine, Bat, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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SMAD7 Antibody (aa320-398) LS-C39135

Antibody:

SMAD7 Mouse anti-Human Monoclonal (aa320-398) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$962

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Mouse SMAD7 (Sandwich ELISA) ELISA Kit - LS-F33521

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse SMAD7 (Sandwich ELISA) ELISA Kit - LS-F12618

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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SMAD7 Antibody (Internal) LS-C137159

Antibody:

SMAD7 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$332

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Rat SMAD7 (Sandwich ELISA) ELISA Kit - LS-F4517

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$818

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SMAD7 Antibody LS-C484812

Antibody:

SMAD7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

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SMAD7 Antibody (aa12-29, Azide-free) LS-C147986

Antibody:

SMAD7 Rabbit anti-Human Polyclonal (aa12-29) (Azide-free) Antibody

Reactivity:

Dog, Bovine, Bat, Human, Monkey

Applications:

WB

Format:

Unconjugated, Azide-free

Price:

100 µg/$386

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IHC-plus™ SMAD7 Antibody (aa49-317) LS-B11606

(4.0) Rating

Antibody:

SMAD7 Rabbit anti-Human Polyclonal (aa49-317) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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Guinea pig SMAD7 (Sandwich ELISA) ELISA Kit - LS-F45802

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Human SMAD7 (Sandwich ELISA) ELISA Kit - LS-F12617

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Select

Human SMAD7 (Sandwich ELISA) ELISA Kit - LS-F4518

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$764

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Human SMAD7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115654

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.2 kDa

Price:

100 µg/$494

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SMAD7 Antibody LS-C833743

Antibody:

SMAD7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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SMAD7 Antibody LS-C832606

Antibody:

SMAD7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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SMAD7 Antibody LS-C747455

Antibody:

SMAD7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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SMAD7 Antibody LS-C405806

Antibody:

SMAD7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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SMAD7 Antibody LS-C408287

Antibody:

SMAD7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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SMAD7 Antibody LS-C832843

Antibody:

SMAD7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

SMAD7 Antibody LS-C753000

Antibody:

SMAD7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

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SMAD7 Antibody LS-C779132

Antibody:

SMAD7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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SMAD7 Antibody LS-C801288

Antibody:

SMAD7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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SMAD7 Antibody LS-C770718

Antibody:

SMAD7 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

SMAD7 Antibody (aa12-18) LS-C10232

Antibody:

SMAD7 Rabbit anti-Human Polyclonal (aa12-18) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$649

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SMAD7 Antibody (aa230-426) LS-C311805

Antibody:

SMAD7 Rabbit anti-Human Polyclonal (aa230-426) Antibody

Reactivity:

Mouse, Bovine, Rat, Pig, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$450

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