SMAD4

SMAD family member 4

In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

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Antibodies (116)

ELISA Kits (18)

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SMAD4 (142)

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Human (91)

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Bat (1)

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SMAD4 Antibody LS-C743631

Antibody:

SMAD4 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated

Price:

0.1 ml/$302

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SMAD4 Antibody (C-Terminus) LS-C75858

Antibody:

SMAD4 Rabbit anti-Human Monoclonal (C-Terminus) Antibody

Applications:

Flo, ICC, IHC, IP, WB

Format:

Unconjugated

Price:

100 µl/$542

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SMAD4 Antibody LS-C812772

Antibody:

SMAD4 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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SMAD4 Antibody (clone 4G1C6) LS-C169242

Antibody:

SMAD4 Mouse anti-Human Monoclonal (4G1C6) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$435

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SMAD4 Antibody (clone 4G1C6) LS-C171509

Antibody:

SMAD4 Mouse anti-Human Monoclonal (4G1C6) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 ml/$393

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SMAD4 Antibody (N-Terminus) LS-C352478

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Zebrafish, Pig, Rat, Mouse, Bovine, Human, Monkey

Applications:

ICC, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µl/$299

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SMAD4 Antibody (aa407-436) LS-C161299

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (aa407-436) Antibody

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated

Price:

400 µl/$393

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SMAD4 Antibody (40-120 aa, N-terminal) LS-C386095

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (40-120 aa, N-terminal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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SMAD4 Antibody (phospho-Thr277, Biotin) LS-C226359

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (pThr277) (Biotin) Antibody

Reactivity:

Human

Applications:

DB, ELISA, ICC, IF, IHC, IHC-P

Format:

Biotin Conjugated

Price:

200 µl/$952

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SMAD4 Antibody (phospho-Thr277, FITC) LS-C226360

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (pThr277) (FITC) Antibody

Reactivity:

Human

Applications:

DB, ELISA, ICC, IF, IHC, IHC-P

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SMAD4 Antibody (phospho-Thr277, APC) LS-C226357

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (pThr277) (APC) Antibody

Reactivity:

Human

Applications:

DB, ELISA, ICC, IF, IHC, IHC-P

Format:

APC Conjugated

Price:

200 µl/$952

Select

SMAD4 Antibody (phospho-Thr277, Azide-free, HRP) LS-C226361

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (pThr277) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

DB, ELISA, ICC, IF, IHC, IHC-P

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

SMAD4 Antibody (phospho-Thr277, PE) LS-C226362

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (pThr277) (PE) Antibody

Reactivity:

Human

Applications:

DB, ELISA, ICC, IF, IHC, IHC-P

Format:

PE Conjugated

Price:

200 µl/$952

• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Biotin
• FITC
• APC
• More...
  • HRP, Azide-free
  • PE

Select

SMAD4 Antibody LS-C334197

Antibody:

SMAD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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SMAD4 Antibody (N-Terminus) LS-B11491

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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SMAD4 Antibody LS-C836184

Antibody:

SMAD4 Rabbit Recombinant Monoclonal Antibody

Applications:

Flo, ICC, IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$299; 100 µl/$548

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SMAD4 Antibody (Thr277, Biotin) LS-C226365

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (Thr277) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

SMAD4 Antibody (Thr277, FITC) LS-C226366

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (Thr277) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SMAD4 Antibody (Thr277, APC) LS-C226364

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (Thr277) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

SMAD4 Antibody (Thr277, Azide-free, HRP) LS-C226367

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (Thr277) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

SMAD4 Antibody (Thr277, PE) LS-C226369

Antibody:

SMAD4 Rabbit anti-Human Polyclonal (Thr277) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Biotin
• FITC
• APC
• More...
  • HRP, Azide-free
  • PE

Select

SMAD4 Antibody LS-C752466

Antibody:

SMAD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

SMAD4 Antibody LS-C752468

Antibody:

SMAD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

SMAD4 Antibody LS-C752467

Antibody:

SMAD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

Mouse/Human/Rat SMAD4 (Cell-Based ELISA) ELISA Kit - LS-F2315

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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