Synthetic peptide from the C-Terminus of human SMAD1/2/3/5 (GPLQWLDKVLTQMGS, aa442-456 of UniProt Q15797). Percent identity by BLAST analysis: Human, Mouse, Ferret, Sheep, Cat, Bovine, Hamster, Elephant, Rabbit, Horse, Pig, Turkey, Chicken, Platypus, Lizard, Xenopus, Trout, Pufferfish, Zebrafish, Stickleback, Sea squirt, Trichina worm, Dog (100%).
SMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs/CoSMAD, act as transcription factors that regulate the expression of certain genes. Zhu, H et al concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-beta superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
Reconstitute in sterile distilled water.
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
For research use only. Intended for use by laboratory professionals.
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