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SLC7A8 / LAT2
solute carrier family 7 (amino acid transporter light chain, L system), member 8
Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
| Gene Name: | solute carrier family 7 (amino acid transporter light chain, L system), member 8 |
| Family/Subfamily: | Transporter , Cationic amino acid transporter |
| Synonyms: | SLC7A8, HLAT2, LPI-PC1, Integral membrane protein E16H |
| Target Sequences: | NM_012244 NP_036376.2 Q9UHI5 |
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