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Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Gene Name: | Src-like-adaptor |
Family/Subfamily: | Protein Kinase Non Catalytic , not assigned-Protein Kinase Non Catalytic |
Synonyms: | SLA, SLA1, SLAP, Src-like-adapter, Src-like-adapter protein 1, SLAP-1, HSLAP, SLAP1, Src-like-adaptor |
Target Sequences: | NM_001045556 NP_006739.2 Q13239 |
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