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SETD8 / SET8

SET domain containing (lysine methyltransferase) 8

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.

Gene Name: SET domain containing (lysine methyltransferase) 8
Synonyms: SETD8, KMT5A, Lysine N-methyltransferase 5A, PR/SET07, PRSET7, SET8, H4-K20-HMTase SETD8, PR-Set7, SET07
Target Sequences: NM_020382 NP_065115.3 Q9NQR1

Publications (1)

1
An epigenetic regulator-related score (EpiScore) predicts survival in patients with diffuse large B cell lymphoma and identifies patients who may benefit from epigenetic therapy. Szablewski V, Bret C, Kassambara A, Devin J, Cartron G, Costes-Martineau V, Moreaux J. Oncotarget. 2018 April;9:19079-19099. (Human) [Full Text Article] [PubMed:29721185] [PMC:PMC5922379] Related Antibodies: LS-B5237.

☰ Filters
Antibodies (75)
Proteins (4)
ELISA Kits (3)
Custom (3)
Over-Expression Lysate (2)
Primary (75)
Recombinant (2)
SETD8 / SET8 (82)
Human (75)
Mouse (26)
Rat (5)
Bovine (1)
IHC (30)
IHC-P (6)
WB (63)
Flo (2)
ELISA (40)
ICC (14)
IF (11)
IP (1)
rabbit (47)
mouse (28)
Product Group
IHCPlus (2)
IgG (34)
IgG1 (24)
IgG2a (4)
monoclonal mc (28)
polyclonal pc (47)
43AT551.86 (1)
43AT551.86.76 (1)
43AT890 (1)
7H1G10 (1)
OTI2B3 (2)
OTI2F5 (2)
OTI2H5 (2)
OTI3G9 (2)
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OTI5E5 (2)
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aa25-53 (7)
aa362-393 (7)
aa220-249 (1)
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293T Cells (1)
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HEK 293 Cells (1)
Purified (1)
SETD8 / SET8 Antibody - Anti-SETD8 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (43AT551.86) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
SETD8 / SET8 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SETD8 / SET8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
SETD8 / SET8 Antibody - Immunofluorescent analysis of Pr-Set7 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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SETD8 / SET8 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
SETD8 / SET8 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
SETD8 / SET8 Antibody - Immunofluorescence analysis of Hela cells using KMT5A mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
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SETD8 / SET8 Mouse anti-Human Monoclonal (7H1G10) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
100 µg/$459
SETD8 / SET8 Antibody - The anti-SET07 antibody is used in Western blot to detect SET07 in 293 cells.
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SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (43AT890) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
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SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
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SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (Biotin) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (FITC) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (PE) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
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SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (APC) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
SETD8 / SET8 Antibody - Immunohistochemical of paraffin-embedded H.breast carcinoma section using SET07 Antibody. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
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SETD8 / SET8 Mouse anti-Human Monoclonal (43AT551.86.76) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SETD8 / SET8 Antibody - SETD8 Antibody (RB18964) IHC of formalin-fixed and paraffin-embedded human testis tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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SETD8 / SET8 Rabbit anti-Human Polyclonal (aa220-249) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SETD8 / SET8 Antibody - Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-SETD8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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SETD8 / SET8 Mouse anti-Human Monoclonal (OTI3G9) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
SETD8 / SET8 Antibody - Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-SETD8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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SETD8 / SET8 Mouse anti-Human Monoclonal (Carrier-free) (OTI3G9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SETD8 / SET8 Antibody - Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-SETD8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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SETD8 / SET8 Mouse anti-Human Monoclonal (OTI2F5) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
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SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
Select
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
SETD8 / SET8 Antibody - Immunohistochemistry of paraffin-embedded human thyroid tissue at dilution of 1:100
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SETD8 / SET8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Select
SETD8 / SET8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
Viewing 1-25 of 82 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).