Human SELL / L-Selectin / CD62L
SELL | CD62L | CD62L antigen | LAM-1 | LAM1 | LECAM1 | LEU8 | Leukocyte adhesion molecule 1 | Lyam-1 | LSEL | gp90-MEL | HLHRc | PLNHR | L-selectin | Leu-8 | Selectin L | LNHR | LYAM1 | Lymph node homing receptor | Lymphocyte adhesion molecule 1 | TQ1 | Pln homing receptor | CD26L
(tested or 100% immunogen sequence identity)
PHA stimulated lymphoblasts.
Recognizes human CD62L, also known a L-selectin, a 74-95kD member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naÃ-ve lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.