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SCN1B

sodium channel, voltage-gated, type I, beta subunit

Scn1b encodes one type of beta subunit found in voltage-gated sodium channels. These channels, composed of one alpha and one or two different beta subunits, mediates changes in cell permeability to sodium ions that are essential for the generation of action potentials. Scn1b protein is comprised of an extracellular N-terminus and a single transmembrane domain. Scn1b is considered an auxiliary subunit that modulates channel gating as well as plasma membrane expression levels. At least two mRNA variants, resulting from intron retention in the longer form, have been reported. A mutation in the extracellular immunoglobulin domain of Scn1b protein has been linked to 'generalized epilepsy with febrile seizures plus type 1' (GEFS+1). Mutations in the Scn1b gene may also be responsible for severe myoclonic epilepsy in infancy (SME).

Gene Name: sodium channel, voltage-gated, type I, beta subunit
Family/Subfamily: Ion Channel , Sodium channel - voltage-gated
Synonyms: SCN1B, GEFS+1, Sodium channel subunit beta-1, GEFSP1, Sodium channel beta-1 subunit
Target Sequences: NM_001037 NP_001028.1 Q07699

☰ Filters
Antibodies (23)
Proteins (5)
Over-Expression Lysate (4)
Primary (23)
Recombinant (1)
SCN1B (28)
Human (22)
Mouse (17)
Rat (11)
Bat (3)
Bovine (3)
Chimpanzee (6)
Dog (6)
Gibbon (3)
Guinea pig (6)
Monkey (6)
Orangutan (3)
Pig (3)
Rabbit (6)
IHC (12)
IHC-P (6)
WB (21)
Flo (7)
ELISA (7)
IP (2)
Peptide-ELISA (1)
rabbit (23)
Product Group
IHCPlus (2)
IgG (13)
polyclonal pc (23)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
Magnetic beads Conjugated (1)
PE Conjugated (1)
Sepharose Conjugated (1)
Unconjugated (10)
aa63-90 (7)
N-Terminus (4)
aa110-159 (4)
aa58-107 (4)
No (28)
GST (1)
Myc-DDK (Flag) (4)
Human (3)
293T Cells (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
SCN1B Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SCN1B Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
SCN1B Antibody - SCN1B Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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SCN1B Rabbit anti-Human Polyclonal (aa63-90) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SCN1B Antibody - Anti-SCN1B antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SCN1B Rabbit anti-Human Polyclonal (aa110-159) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SCN1B Antibody - Anti-SCN1B antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SCN1B Rabbit anti-Human Polyclonal (aa110-159) (HRP) Antibody
Rabbit, Dog, Guinea pig, Human, Monkey, Chimpanzee, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
SCN1B Antibody - Anti-SCN1B antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SCN1B Rabbit anti-Human Polyclonal (aa110-159) (Biotin) Antibody
Rabbit, Dog, Guinea pig, Human, Monkey, Chimpanzee, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
SCN1B Antibody - Anti-SCN1B antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SCN1B Rabbit anti-Human Polyclonal (aa110-159) (FITC) Antibody
Rabbit, Dog, Guinea pig, Human, Monkey, Chimpanzee, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
Select
SCN1B Rabbit anti-Human Polyclonal (aa63-90) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
Select
SCN1B Rabbit anti-Human Polyclonal (aa63-90) (Biotin) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
Select
SCN1B Rabbit anti-Human Polyclonal (aa63-90) (FITC) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
Select
SCN1B Rabbit anti-Human Polyclonal (aa63-90) (PE) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
Select
SCN1B Rabbit anti-Human Polyclonal (aa63-90) (APC) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
Select
SCN1B Rabbit anti-Human Polyclonal (aa63-90) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
SCN1B Protein - 12.5% SDS-PAGE of human SCN1B stained with Coomassie Blue
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Wheat Germ Extract
GST
49.61 kDa
2 µg/$439
Select
SCN1B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
SCN1B Antibody - Western blot analysis SCN1B using HepG2 whole cells lysates
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SCN1B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
SCN1B Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$564
SCN1B Antibody - Western blot analysis of extracts of various cell lines, using SCN1B antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 60s.
Select
SCN1B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SCN1B Antibody
Select
SCN1B Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
SCN1B Antibody - SCN1B antibody Western Blot of Rat Thymus.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SCN1B Rabbit anti-Rat Polyclonal (aa58-107) Antibody
Rat
WB
Unconjugated
100 µl/$424
SCN1B Antibody - SCN1B antibody Western Blot of Rat Thymus.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SCN1B Rabbit anti-Rat Polyclonal (aa58-107) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Bat, Orangutan, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$469
SCN1B Antibody - SCN1B antibody Western Blot of Rat Thymus.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SCN1B Rabbit anti-Rat Polyclonal (aa58-107) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Bat, Orangutan, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
SCN1B Antibody - SCN1B antibody Western Blot of Rat Thymus.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SCN1B Rabbit anti-Rat Polyclonal (aa58-107) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Bat, Orangutan, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
Select
SCN1B Rabbit anti-Human Polyclonal (N-Terminus) (Sepharose) Antibody
Mouse, Rat, Human
IP
Sepharose Conjugated
100 µg/$399
Select
SCN1B Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
SCN1B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
24.5 kDa
20 µg/$150
Viewing 1-25 of 28 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).