Target
Human S1PR1 / EDG1 / S1P1
Synonyms
S1PR1 | CD363 | CD363 antigen | CHEDG1 | ECGF1 | EDG-1 | D1S3362 | EDG1 | S1P1 | S1P receptor Edg-1 | S1P receptor 1
Reactivity
Human, Mouse, Rat
(tested or 100% immunogen sequence identity)
Conjugations
Unconjugated
Purification
Protein A purified
Immunogen
A recombinant protein fragment from the C-Terminus portion of human EDG1.
Specificity
Human S1PR1 / EDG1 / S1P1.
Applications
- Western blot (4 - 6 µg/ml)
Usage
EDG1 (Endothelial differentiation gene 1), also called Sphingosine-1-phosphate receptor 1 (S1PR1) is the G-protein coupled receptor for Sphingosine 1-phosphate (S1P). Via its interaction with S1P, EDG1 is involved in a number of cellular processes. The binding of S1P leads to angiogenesis and tumor cell motility in cancer, and this interaction also participates in the formation of cell-cell adherens junctions. During embryogenesis, it regulates vascularization. EDG1 interacts with the serotonin receptor 5-HT1AR in the central nervous system. It is also a regulator of innate and adaptive immunity by signaling the release of T-cells from lymph nodes.
Presentation
1X PBS, pH 7.4, 0.1 mg/ml BSA, 0.05% Sodium Azide
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About S1PR1 / EDG1 / S1P1